p63 antibody
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Rabbit anti p63 (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- p63
- Region
- (C-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti p63 antibody recognizes an epitope within the C-terminal (CT) region of tumour protein p63, otherwise known as tumour protein p73-like (p73L), a widely expressed nuclear protein and homologue of tumour suppressor p53, which acts as a sequence-specific DNA binding transcriptional activator/repressor. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. Rabbit anti p63 antibody is reported as suitable for use in immunocytochemistry. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human p63 (CT) was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin - Immunogen
- Synthetic peptide C-NFDMDARRNKQQRIKEEGE corresponding to amino acids 662-680 within the C-terminal region of p63.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/100000 | |
| Western Blotting | |
1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti Human p63 antibody detects a band of approximately 75kDa in mouse lung and human tumour cell line K562 (protein degredation is as expected).
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- Synonyms
- p73L
- RRID
- AB_1720115
- UniProt
- Q9H3D4
- O88898
- Entrez Gene
- Trp63
- TP63
- GO Terms
- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
- GO:0005515 protein binding
- GO:0001501 skeletal system development
- GO:0001736 establishment of planar polarity
- GO:0002053 positive regulation of mesenchymal cell proliferation
- GO:0002064 epithelial cell development
- GO:0002347 response to tumor cell
- GO:0003682 chromatin binding
- GO:0003684 damaged DNA binding
- View More GO Terms
- GO:0005634 nucleus
- GO:0006916 anti-apoptosis
- GO:0007219 Notch signaling pathway
- GO:0007499 ectoderm and mesoderm interaction
- GO:0008270 zinc ion binding
- GO:0009954 proximal/distal pattern formation
- GO:0010259 multicellular organismal aging
- GO:0030216 keratinocyte differentiation
- GO:0030308 negative regulation of cell growth
- GO:0030326 embryonic limb morphogenesis
- GO:0030859 polarized epithelial cell differentiation
- GO:0031069 hair follicle morphogenesis
- GO:0035121 tail morphogenesis
- GO:0042475 odontogenesis of dentine-containing tooth
- GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- GO:0043565 sequence-specific DNA binding
- GO:0043589 skin morphogenesis
- GO:0043616 keratinocyte proliferation
- GO:0045617 negative regulation of keratinocyte differentiation
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0048485 sympathetic nervous system development
- GO:0048745 smooth muscle tissue development
- GO:0048807 female genitalia morphogenesis
- GO:0051402 neuron apoptosis
- GO:0060157 urinary bladder development
- GO:0060197 cloacal septation
- GO:0060513 prostatic bud formation
- GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
AHP1815
155949
160120
161157
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