p27/Kip1 antibody

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WB ResetRabbit anti p27/Kip1
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- p27/Kip1
Rabbit anti p27/Kip1 antibody recognizes cyclin-dependent kinase inhibitor p27 (p27), also known as cyclin-dependent kinase inhibitor 1B or p27Kip1. The protein is a cyclin-dependent kinase inhibitor (CKI) that belongs to the Cip/Kip protein family (Cerqueira et al. 2014). As the name implies, CKIs play a role in the regulation of cyclin-dependent kinases (CDKs) and cyclin-CDK complexes (Cerqueira et al. 2014). Aberrant p27Kip1. levels have been reported in breast and colorectal cancers (Sgambato et al. 1997, Ogino et al. 2007). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Antiserum Preparation
- Antiserum to p27/Kip1 was raised by repeated immunisation of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.2% Gelatin - Immunogen
- Peptide mapping to the carboxy terminus of human p27/Kip1
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | ![]() |
1/200 |
- Western Blotting
- Rabbit anti p27/Kip1 reconizes a band of approximately 27 kDa when run under reducing conditions
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Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE |
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TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
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Description | TidyBlot Western Blot Detection Reagent:HRP |
- UniProt
- P46527
- Entrez Gene
- CDKN1B
- GO Terms
- GO:0000079 regulation of cyclin-dependent protein kinase activity
- GO:0000080 G1 phase of mitotic cell cycle
- GO:0000082 G1/S transition of mitotic cell cycle
- GO:0000084 S phase of mitotic cell cycle
- GO:0005829 cytosol
- GO:0004861 cyclin-dependent protein kinase inhibitor activity
- GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
- GO:0005654 nucleoplasm
- GO:0006917 induction of apoptosis
- View More GO Terms
- GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- GO:0007050 cell cycle arrest
- GO:0048102 autophagic cell death
- GO:0008285 negative regulation of cell proliferation
- GO:0019903 protein phosphatase binding
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030308 negative regulation of cell growth
- GO:0032582 negative regulation of gene-specific transcription
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0071285 cellular response to lithium ion
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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