OPA1 antibody
Rabbit anti Human OPA1 antibody recognizes OPA1, also known as dynamin-like 120 kDa protein-mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, NTG and optic atrophy protein 1.
OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in OPA1 have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for OPA1 (provided by RefSeq, Mar 2009).
Rabbit anti Human OPA1 antibody detects bands of 80-100 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in OPA1 have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for OPA1 (provided by RefSeq, Mar 2009).
Rabbit anti Human OPA1 antibody detects bands of 80-100 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti OPA1 antibody recognizes a band of approximately 80-100 kDa in LNCaP cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
<50% Glycerol - Immunogen
- Recombinant protein of human OPA1
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- As supplied, 12 months from date of despatch
More Information
- UniProt
- O60313 Related reagents
- Entrez Gene
- OPA1 Related reagents
- GO Terms
- GO:0003924 GTPase activity
- GO:0000266 mitochondrial fission
- GO:0000287 magnesium ion binding
- GO:0006915 apoptosis
- GO:0016021 integral to membrane
- GO:0005525 GTP binding
- GO:0005741 mitochondrial outer membrane
- GO:0005758 mitochondrial intermembrane space
- GO:0007007 inner mitochondrial membrane organization
- GO:0007601 visual perception
- GO:0008053 mitochondrial fusion
- GO:0019896 axon transport of mitochondrion
- GO:0030061 mitochondrial crista
- GO:0030425 dendrite
- GO:0045768 positive regulation of anti-apoptosis
- GO:0050896 response to stimulus
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of OPA1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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