OPA1 antibody

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Rabbit anti OPA1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00896
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human OPA1 antibody recognizes OPA1, also known as dynamin-like 120 kDa protein-mitochondrial, dynamin-like guanosine triphosphatase, mitochondrial dynamin-like GTPase, NTG and optic atrophy protein 1.

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in OPA1 have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for OPA1 (provided by RefSeq, Mar 2009).

Rabbit anti Human OPA1 antibody detects bands of 80-100 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti OPA1 antibody recognizes a band of approximately 80-100 kDa in LNCaP cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
<50% Glycerol
Immunogen
Recombinant protein of human OPA1

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
As supplied, 12 months from date of despatch

More Information

UniProt
O60313 Related reagents
Entrez Gene
OPA1 Related reagents
GO Terms
GO:0003924 GTPase activity
GO:0000266 mitochondrial fission
GO:0000287 magnesium ion binding
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0005525 GTP binding
GO:0005741 mitochondrial outer membrane
GO:0005758 mitochondrial intermembrane space
GO:0007007 inner mitochondrial membrane organization
GO:0007601 visual perception
GO:0008053 mitochondrial fusion
GO:0019896 axon transport of mitochondrion
GO:0030061 mitochondrial crista
GO:0030425 dendrite
GO:0045768 positive regulation of anti-apoptosis
GO:0050896 response to stimulus
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of OPA1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml

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