Ocil antibody
Goat anti Human OCIL antibody recognizes c-type lectin domain family 2 member D, also known as CLC2D, CLAX, and LLT1.
Originally described as an osteoblast-derived inhibitory factor of osteoclasts (Zhou et al. 2001), OCIL is a member of the C-type lectin-like receptor superfamily (CTLR). OCIL is expressed on lymphocytes including B cells, NK cells, T cells, and activated dendritic cells. At the cell surface, OCIL acts as a ligand for the NKRP1A receptor (CD161), which contributes to differentiation of lymphocytes (Marrufo et al. 2018). Interaction between OCIL and CD161 appears to actively participate in the anti-tumoral immune response, and have both been suggested as targets for immunotherapy strategies to enhance immune responses (Braud et al. 2018). The suggestion of OCIL as a target for immunotherapy has been strengthened by the finding that it is expressed in a variety of healthy tissues and in immune-privileged sites (Llibre et al. 2016).
Originally described as an osteoblast-derived inhibitory factor of osteoclasts (Zhou et al. 2001), OCIL is a member of the C-type lectin-like receptor superfamily (CTLR). OCIL is expressed on lymphocytes including B cells, NK cells, T cells, and activated dendritic cells. At the cell surface, OCIL acts as a ligand for the NKRP1A receptor (CD161), which contributes to differentiation of lymphocytes (Marrufo et al. 2018). Interaction between OCIL and CD161 appears to actively participate in the anti-tumoral immune response, and have both been suggested as targets for immunotherapy strategies to enhance immune responses (Braud et al. 2018). The suggestion of OCIL as a target for immunotherapy has been strengthened by the finding that it is expressed in a variety of healthy tissues and in immune-privileged sites (Llibre et al. 2016).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human OCIL were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin - Immunogen
- Peptide with sequence C-LLRYKGPSDH, from the Internal region of the protein sequence according to NP_037401.1; NP_001004419.1; NP_001184246.1.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- Regulatory
- For research purposes only
Applications of Ocil antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 3 µg/ml | 0.5 µg/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Goat anti Human OCIL antibody detects a band of approximately 30 to 35 kDa in cell lysates.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Rabbit anti Goat IgG (Fc):HRP | STAR122P | C E WB | 1 mg |
|
|
| Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
|
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