NXF1 antibody

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Anti NXF1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with NXF1 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000,STAR208P) and visualized on the ChemiDoc MP with 15 second exposure. Arrow points to NXF1 (molecular weight 70 kDa)

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Rabbit anti NXF1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: NXF1

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Rabbit anti Human NXF1 antibody recognizes NFX1, also known as mRNA export factor TAP and tip-associated protein.

The NXF1 gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family include a non-canonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows hetero-dimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleo-porins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in NXF1 family. The encoded protein of NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jul 2008).

Rabbit anti Human NXF1 antibody detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti NXF1 detects a band of approximately 70 kDa in Jurkat cell lysate.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH-conjugated synthetic peptide corresponding to aa 1-30 of human NXF1
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: Q9UBU9
Entrez Gene: NXF1
GO Terms: GO:0000166 nucleotide binding; GO:0005515 protein binding; GO:0005829 cytosol; GO:0010467 gene expression; GO:0016607 nuclear speck; GO:0044419 interspecies interaction between organisms