NUP62 antibody

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Rabbit anti NUP62

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00728
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human NUP62 antibody recognizes the nuclear pore glycoprotein p62, also known as 62 kDa nucleoporin or nucleoporin Nup62.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by NUP62 gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of NUP62 encode a single protein isoform (provided by RefSeq, Jul 2008).

Rabbit anti Human NUP62 antibody detects a band of 72 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Rabbit anti NUP62 detects a band of approximately 72 kDa in MOLT-4 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
TRIS buffered glycine
Preservative Stabilisers
0.01% Thiomersal
<50% Glycerol
Immunogen
Recombinant protein encompassing part of the middle region of human NUP62

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
P37198
Entrez Gene
NUP62
GO Terms
GO:0000922 spindle pole
GO:0003682 chromatin binding
GO:0030529 ribonucleoprotein complex
GO:0004674 protein serine/threonine kinase activity
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005975 carbohydrate metabolic process
GO:0007166 cell surface receptor linked signaling pathway
GO:0008219 cell death
GO:0008285 negative regulation of cell proliferation
GO:0016032 viral reproduction
GO:0009755 hormone-mediated signaling pathway
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0046966 thyroid hormone receptor binding
GO:0017056 structural constituent of nuclear pore
GO:0030159 receptor signaling complex scaffold activity
GO:0030528 transcription regulator activity
GO:0031074 nucleocytoplasmic shuttling complex
GO:0031965 nuclear membrane
GO:0042169 SH2 domain binding
GO:0043066 negative regulation of apoptosis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043130 ubiquitin binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045941 positive regulation of transcription
GO:0051028 mRNA transport
GO:0055085 transmembrane transport
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of NUP62 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml