NPM antibody
NPM is a mobile protein which shuttles between the nucleolus and cytoplasm depending upon growth conditions and ATP/GTP levels, and is also influenced by cytotoxic drugs including actinomycin D and camptothecin. NPM interacts with numerous proteins including p19ARF, transcription factor YY1 and nucleolar p120, and is known to regulate the stability and transcriptional activity of p53, a tumor suppressor protein activated in response to DNA damage, capable of inducing cell cycle arrest and apoptosis.
Goat anti Human NPM antibody detects nucleophosmin as a single band of 38 kDa in a range of human cell lysates tested.
Product Details
- Target Species
- Human
- Western Blotting
- Goat anti NPM detects a band of approximately 38 kDa in K562 cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Goat polyclonal antibody purified by affinity chromatography
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Peptide with sequence C-QEAIQDLWQWRKSL from the C terminus of the protein sequence.
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P06748
- Entrez Gene
- NPM1
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of NPM antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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