Noxa is a transcriptional target of p53, p73 and BH3-only proteins, and competes with, and displaces, the proapoptotic proteins BAK1, and BIM, from the antiapoptotioc protein MCL1 (Bcl-2-related protein EAT/mcl1), thereby influencing apoptosis versus cell survival.
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human NOXA was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
- Synthetic peptide sequence C-TQLRRFGDKLNFRQK from the internal region of Noxa (NP_066950.1).
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Q13794 Related reagents
- Entrez Gene
- PMAIP1 Related reagents
- GO Terms
- GO:0005515 protein binding
- GO:0001836 release of cytochrome c from mitochondria
- GO:0005829 cytosol
- GO:0005741 mitochondrial outer membrane
- GO:0006919 activation of caspase activity
- GO:0006921 cellular component disassembly involved in apoptosis
- GO:0006926 virus-infected cell apoptosis
- GO:0008629 induction of apoptosis by intracellular signals
- GO:0008633 activation of pro-apoptotic gene products
- GO:0043331 response to dsRNA
- For research purposes only
Applications of Noxa antibody
|Application Name||Verified||Min Dilution||Max Dilution|
- Western Blotting
- AHP2170 detects a band of approximately 16kDa in human cerebellum cell lysates.
Suitable loading control:
Goat anti Human GAPDH; product code(AHP1064)
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||F||1 mg|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||C E WB||1 mg|
Product Specific References
References for Noxa antibody
Yu, S.J. et al. (2013) MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer.
Clin Cancer Res. 19 (6): 1389-99.
Ikezoe, T. et al. (2010) p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells.
Int J Hematol. 91: 69-77.
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