NFkB p105 (pSer932) antibody
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WB P ResetRabbit anti NFkB p105 (pSer932)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- NFkB p105 (pSer932)
Antibody Quality and Performance Guarantee
| Rabbit anti NFkB p105 (pSer932) antibody recognizes human nuclear factor NF-kappa-B (NFkB) p105 subunit, also known as DNA-binding factor KBF1, EBP-1 or nuclear factor of kappa light polypeptide gene enhancer in B-cells,when phosphorylated at serine 932. NFkB p105 is a large precursor protein that is cleaved at its C-terminus (which mainly contains ankyrin repeats) by the ubiquitin/proteasome pathway into the NFkB p50 subunit. The p50 subunit is also known as NFkB1 and interacts with members of the Rel protein family to form transcription factors. The NF-kappa-B pathway plays a critical role in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer. NFkB p105 is phosphorylated at serine 927 and serine 932 by the IκB kinase (IKK) complex. Phosphorylation at serines 927 and 932 is required for TNF-alpha induced degradation of NFkB p105 (Lang et al. 2003). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to NFkB p105 (pSer932) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding serine 932 of human NFkB p105
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/100 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Lang, V. et al. (2003) betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
Mol Cell Biol. 23 (1): 402-13.
- UniProt
- P19838
- Entrez Gene
- NFKB1
- GO Terms
- GO:0005515 protein binding
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0006915 apoptosis
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005654 nucleoplasm
- GO:0006366 transcription from RNA polymerase II promoter
- View More GO Terms
- GO:0006916 anti-apoptosis
- GO:0006954 inflammatory response
- GO:0008063 Toll signaling pathway
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010744 positive regulation of macrophage derived foam cell differentiation
- GO:0010843 promoter binding
- GO:0010884 positive regulation of lipid storage
- GO:0010956 negative regulation of calcidiol 1-monooxygenase activity
- GO:0010957 negative regulation of vitamin D biosynthetic process
- GO:0016563 transcription activator activity
- GO:0031293 membrane protein intracellular domain proteolysis
- GO:0032269 negative regulation of cellular protein metabolic process
- GO:0032375 negative regulation of cholesterol transport
- GO:0033256 I-kappaB/NF-kappaB complex
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0045087 innate immune response
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0050852 T cell receptor signaling pathway
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0090263 positive regulation of canonical Wnt receptor signaling pathway
AHP2660
141617
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