NFkB p100 (pSer870) antibody

Rabbit anti NFkB p100 (pSer870)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
NFkB p100 (pSer870)

Product Code Applications Pack Size List Price Your Price Qty
AHP2661
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti NFkB p100 (pSer870) antibody recognizes nuclear factor NF-kappa-B p100 subunit (NFkB p100), also known as lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B subunit 2, nuclear factor of Kappa light chain gene enhancer in B cells 2, oncogene Lyt-10 or transcription factor NFKB2, when phosphorylated at serine 870.

NFkB p100 is a subunit of the NFkB transcription factor complex that is cleaved to form the NFkB p52 subunit. The NFkB pathway plays a critical role in mediating immune responses after infection and has been implicated in a variety of diseases ranging from autoimmune disorders to cancer.

Phosphorylation of NFkB p100 at serine 870 is mediated by MAP3K14 (Xiao et al. 2001).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to NFkB p100 (pSer870) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine 870 of human NFkB p100
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Xiao, G. et al. (2001) NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100.
    Mol Cell. 7 (2): 401-9.

UniProt
Q00653
Entrez Gene
NFKB2
GO Terms
GO:0005515 protein binding
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0008063 Toll signaling pathway
GO:0033257 Bcl3/NF-kappaB2 complex
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0045087 innate immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
View more products with NFKB specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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