Rabbit anti Human NHκB inhibitor alpha antibody recognizes NF-kappa-B inhibitor alpha (also known as IkB alpha), one of seven members of the IkB class of inhibitor proteins that have been identified to date. NFkBIa inhibits the NFkB complex in unstimulated cells through non-covalent binding. Following stimulation of cells, IkB alpha is phosphorylated so that it dissociates from the NFkB, and then ubiquinated prior to degradation.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- NFκBIa peptide corresponding to a region near the C-terminus of the human protein, conjugated with KLH.
- Approx. Protein Concentrations
- Total protein concentration 80.0 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
cytoplasmic sequestering of NF-kappaB
Toll signaling pathway
nuclear localization sequence binding
identical protein binding
positive regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
negative regulation of lipid storage
ubiquitin protein ligase binding
negative regulation of NF-kappaB transcription factor activity
positive regulation of cellular protein metabolic process
toll-like receptor 1 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
interspecies interaction between organisms
innate immune response
nerve growth factor receptor signaling pathway
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of NF Kappa B Inhibitor Alpha antibody
|Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for NF Kappa B Inhibitor Alpha antibody
Hoffmann, A. et al. (2002) The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation.
Science. 298 (5596): 1241-5.