MNAR antibody

Rabbit anti MNAR

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
MNAR

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VPA00253
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Rabbit anti Human MNAR antibody recognizes modulator of non-genomic activity of estrogen receptor, otherwise known as proline-, glutamic acid-, and leucine-rich protein-1.

A product of the MNAR (PELP1) gene, this protein is a novel steroid co-activator of the estrogen receptor (ER) which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway. MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and SH2-binding which modulates the interaction of the ER to c-Src, leading to MAPK activation. Deregulation of MNAR occurs in breast tumours and endometrial cancers (Nair and Vadlamudi 2007).

Rabbit anti Human MNAR antibody detects a band of 160 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti MNAR detects a band of approximately 160 kDa in HEK293 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH conjugated synthetic peptide between 744-771 amino acids from the central region of human MNAR
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q8IZL8
Entrez Gene
PELP1
GO Terms
GO:0005515 protein binding
GO:0005737 cytoplasm
GO:0006350 transcription
GO:0071339 MLL1 complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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