MNAR antibody

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Anti MNAR Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with MNAR antibody followed by detection with Goat anti Rabbit HRP conjugated(1/10,000, STAR208P) and visualized on the ChemiDoc MP with 7 second exposure. Arrow points to MNAR (molecular weight 160 kDa)

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Rabbit anti MNAR

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: MNAR

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Product Code Applications Pack Size List Price Your Price Qty

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VPA00253 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human MNAR antibody recognizes modulator of non-genomic activity of estrogen receptor, otherwise known as proline-, glutamic acid-, and leucine-rich protein-1.

A product of the MNAR (PELP1) gene, this protein is a novel steroid co-activator of the estrogen receptor (ER) which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway. MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and SH2-binding which modulates the interaction of the ER to c-Src, leading to MAPK activation. Deregulation of MNAR occurs in breast tumours and endometrial cancers (Nair and Vadlamudi 2007).

Rabbit anti Human MNAR antibody detects a band of 160 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti MNAR detects a band of approximately 160 kDa in HEK293 cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide between 744-771 amino acids from the central region of human MNAR
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: Q8IZL8
Entrez Gene: PELP1
GO Terms: GO:0005515 protein binding; GO:0005737 cytoplasm; GO:0006350 transcription; GO:0071339 MLL1 complex