MFN2 antibody

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Anti MFN2 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with MFN2 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 22 second exposure. Arrow points to MFN2 (molecular weight 80 kDa).

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Rabbit anti MFN2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: MFN2

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VPA00448 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human MFN2 antibody recognizes MFN2, also known as hyperplasia suppressor, mitochondrial assembly regulatory factor or transmembrane GTPase MFN2.

The MFN2 gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in MFN2 gene cause Charcot-Marie-Tooth disease type 2A2 (CMT2A2), and hereditary motor and sensory neuropathy VI (HMSN6A), which are both disorders of the peripheral nervous system. Defects in MFN2 have also been associated with early-onset stroke (Chung et al. 2008). Two transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul 2008).

Rabbit anti Human MFN2 antibody detects a band of 80 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti MFN2 detects a band of approximately 80 kDa in Ramos cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide corresponding to amino acid 447-476 of human MFN2
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: O95140
Entrez Gene: MFN2
GO Terms: GO:0003924 GTPase activity; GO:0007596 blood coagulation; GO:0016021 integral to membrane; GO:0005829 cytosol; GO:0005525 GTP binding; GO:0006626 protein targeting to mitochondrion; GO:0007006 mitochondrial membrane organization; GO:0008053 mitochondrial fusion; GO:0031306 intrinsic to mitochondrial outer membrane; View More GO Terms; GO:0031625 ubiquitin protein ligase binding; GO:0046580 negative regulation of Ras protein signal transduction; GO:0048662 negative regulation of smooth muscle cell proliferation; GO:0051646 mitochondrion localization