MFN2 antibody

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Rabbit anti MFN2

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00448
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human MFN2 antibody recognizes MFN2, also known as hyperplasia suppressor, mitochondrial assembly regulatory factor or transmembrane GTPase MFN2.

The MFN2 gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in MFN2 gene cause Charcot-Marie-Tooth disease type 2A2 (CMT2A2), and hereditary motor and sensory neuropathy VI (HMSN6A), which are both disorders of the peripheral nervous system. Defects in MFN2 have also been associated with early-onset stroke (Chung et al. 2008). Two transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul 2008).

Rabbit anti Human MFN2 antibody detects a band of 80 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti MFN2 detects a band of approximately 80 kDa in Ramos cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH conjugated synthetic peptide corresponding to amino acid 447-476 of human MFN2

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
O95140
Entrez Gene
MFN2
GO Terms
GO:0003924 GTPase activity
GO:0007596 blood coagulation
GO:0016021 integral to membrane
GO:0005829 cytosol
GO:0005525 GTP binding
GO:0006626 protein targeting to mitochondrion
GO:0007006 mitochondrial membrane organization
GO:0008053 mitochondrial fusion
GO:0031306 intrinsic to mitochondrial outer membrane
GO:0031625 ubiquitin protein ligase binding
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051646 mitochondrion localization
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of MFN2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml