MEK 4 (pSer257/pThr261) antibody

Rabbit anti MEK 4 (pSer257/pThr261)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
MEK 4 (pSer257/pThr261)

Product Code Applications Pack Size List Price Your Price Qty
AHP2655
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti MEK 4 (pSer257/pThr261) antibody recognizes MAPK/ERK kinase 4 (MEK 4), also known as dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4 (MAPKK 4), stress-activated protein kinase kinase 1 and JNKK, when phosphorylated at serine 257/threonine 261.

MEK 4 is a dual specificity protein kinase and a member of the MAP kinase family. MEK 4 plays a key role in the MAP kinase and SAP/JNK signaling pathways.

MEK 4 is activated by phosphorylation at serine 257 and threonine 261 by MAP kinase kinase kinases (MAP3Ks). Downstream targets of activated MEK4 include JNK1, JNK2 and p38 MAPK.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to MEK 4 (pSer257/pThr261) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine 257/threonine 261 of human MEK 4
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P45985
Entrez Gene
MAP2K4
GO Terms
GO:0005515 protein binding
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005829 cytosol
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0008545 JUN kinase kinase activity
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0045087 innate immune response
GO:0051403 stress-activated MAPK cascade
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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