MEK 4 (pSer257/pThr261) antibody
Rabbit anti MEK 4 (pSer257/pThr261) antibody recognizes MAPK/ERK kinase 4 (MEK 4), also known as dual specificity mitogen-activated protein kinase kinase 4, MAP kinase kinase 4 (MAPKK 4), stress-activated protein kinase kinase 1 and JNKK, when phosphorylated at serine 257/threonine 261.
MEK 4 is a dual specificity protein kinase and a member of the MAP kinase family. MEK 4 plays a key role in the MAP kinase and SAP/JNK signaling pathways.
MEK 4 is activated by phosphorylation at serine 257 and threonine 261 by MAP kinase kinase kinases (MAP3Ks). Downstream targets of activated MEK4 include JNK1, JNK2 and p38 MAPK.
MEK 4 is a dual specificity protein kinase and a member of the MAP kinase family. MEK 4 plays a key role in the MAP kinase and SAP/JNK signaling pathways.
MEK 4 is activated by phosphorylation at serine 257 and threonine 261 by MAP kinase kinase kinases (MAP3Ks). Downstream targets of activated MEK4 include JNK1, JNK2 and p38 MAPK.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to MEK 4 (pSer257/pThr261) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding serine 257/threonine 261 of human MEK 4
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P45985
- Entrez Gene
- MAP2K4
- GO Terms
- GO:0005515 protein binding
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0005829 cytosol
- GO:0004674 protein serine/threonine kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0005524 ATP binding
- GO:0006468 protein phosphorylation
- GO:0007254 JNK cascade
- GO:0008063 Toll signaling pathway
- GO:0008545 JUN kinase kinase activity
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0045087 innate immune response
- GO:0051403 stress-activated MAPK cascade
- Regulatory
- For research purposes only
Applications of MEK 4 (pSer257/pThr261) antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Useful Reagents Available
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| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
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