MEK 2 antibody

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Anti MEK 2 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with MEK 2 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 14 second exposure. Arrow points to MEK 2 (molecular weight 49 kDa).

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Rabbit anti MEK 2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: MEK 2

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Rabbit anti Human MEK 2 antibody recognizes MEK 2 also known as dual specificity mitogen-activated protein kinase kinase 2, also known as ERK activator kinase 2, MAP kinase kinase 2, MAPK/ERK kinase 2, MAPKK2 or p45.

The protein encoded by MAP2K2 gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in MAP2K2 gene cause Cardiofaciocutaneous syndrome 4 (CFC4), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome (Schulz et al. 2008). The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for MAP2K2 (provided by RefSeq, Jul 2008).

Rabbit anti Human MEK 2 antibody detects a band of 49 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti MEK 2 detects a band of approximately 49 kDa in HepG2 cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the N terminal region of human MEK 2
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P36507
Entrez Gene: MAP2K2
GO Terms: GO:0000186 activation of MAPKK activity; GO:0000187 activation of MAPK activity; GO:0005515 protein binding; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0002756 MyD88-independent toll-like receptor signaling pathway; GO:0005576 extracellular region; GO:0005829 cytosol; GO:0004674 protein serine/threonine kinase activity; GO:0004713 protein tyrosine kinase activity; View More GO Terms; GO:0005524 ATP binding; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0007265 Ras protein signal transduction; GO:0007411 axon guidance; GO:0008063 Toll signaling pathway; GO:0008286 insulin receptor signaling pathway; GO:0034130 toll-like receptor 1 signaling pathway; GO:0034134 toll-like receptor 2 signaling pathway; GO:0034138 toll-like receptor 3 signaling pathway; GO:0034142 toll-like receptor 4 signaling pathway; GO:0045087 innate immune response; GO:0048011 nerve growth factor receptor signaling pathway; GO:0051403 stress-activated MAPK cascade; GO:0070371 ERK1 and ERK2 cascade