MDC1 antibody


Product Details
- Target Species
- Human
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to human MDC1 (3838) were raised by repeated immunisations of sheep with highly purified antigen.
- Preservative Stabilisers
0.09% Sodium Azide - Immunogen
- Recombinant MDC1 BRCT domains (aa 1883 - 2089).
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
Applications of MDC1 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | 1/500 | ||
Western Blotting | 1/2000 |
- Western Blotting
- AHP799 detects 3 bands of approximately 250 kDa in HeLa and 293T cell lysates.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
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Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F IF | 0.1 mg |
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Donkey anti Sheep/Goat IgG:FITC | STAR88F | C | 1 mg |
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Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
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Product Specific References
References for MDC1 antibody
-
Goldberg, M. et al. (2003) MDC1 is required for the intra-S-phase DNA damage checkpoint.
Nature. 421 (6926): 952-6. -
Lou, Z. et al. (2003) MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.
Nature. 421 (6926): 957-61. -
Shi, W. et al. (2008) Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent
degradation.
J Biol Chem. 283: 31608-16. -
Rai, R. et al (2008) Differential regulation of centrosome integrity by DNA damage response proteins.
Cell Cycle. 7: 2225-33. -
Ichijima, Y. et al. (2011) MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.
Genes Dev. 25: 959-71. -
Sin, H.S. et al. (2012) Human postmeiotic sex chromatin and its impact on sex chromosome evolution.
Genome Res. 22: 827-36. -
Nakada, S. et al. (2008) PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.
EMBO Rep. 9: 1019-26. -
Nakada, S. et al. (2010) Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature. 466: 941-6. -
Reichert, S. et al. (2011) Survivin inhibition and DNA double-strand break repair: A molecular mechanism to overcome radioresistance in glioblastoma
Radiother Oncol. 101: 51-8. -
Capalbo, G. et al. (2010) Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
Int J Radiat Oncol Biol Phys. 77 (1): 226-34. -
Cloutier, J.M. et al. (2016) Mammalian meiotic silencing exhibits sexually dimorphic features.
Chromosoma. 125 (2): 215-26. -
Kato, Y. et al. (2015) FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.
Hum Mol Genet. 24 (18): 5234-49.
Further Reading
-
Stewart, G.S. et al. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint.
Nature. 421 (6926): 961-6.
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