MCM6 antibody
Filter by Application:
WB ResetRabbit anti MCM6
- Product Type
- PrecisionAb Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- MCM6
Quick Links:
Antibody Quality and 
Unrivaled 
| Rabbit anti Human MCM6 antibody recognizes human minichromosome maintenance 6 (MCM6), also known as DNA replication licensing factor or p105MCM. MCM6 is a 821 amino acid nuclear component of the MCM complex containing a single MCM domain. MCM6 is involved in the initiation and control of eukaryotic DNA replication. MCM6 forms a hexameric protein complex with MCM4 and 7, which has DNA helicase activity and may act as a DNA unwinding enzyme (Kanter et al. 2008). The phosphorylation of this complex by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex (Ishimi et al. 2001). MCM6 has been noted to have elevated expression in Hodgkin's lymphoma (Karimi et al. 2008) and be a predictor of survival in patients with mantle cell lymphoma (Schrader et al. 2005). Rabbit anti Human MCM6 antibody recognizes human MCM6 as a single band of ~105 kDa in multiple human cell line lysates by western blotting under reducing conditions. It also cross reacts with rodent cell lines tested. |
|
- Target Species
- Human
- Western Blotting
- Anti MCM6 antibody detects a band of approximately 105 kDa in HeLa cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- TRIS buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3).
- Immunogen
- Synthetic peptide corresponding to a region within human MCM6
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
- UniProt
- Q14566
- Entrez Gene
- MCM6
- GO Terms
- GO:0000075 cell cycle checkpoint
- GO:0000082 G1/S transition of mitotic cell cycle
- GO:0000084 S phase of mitotic cell cycle
- GO:0000216 M/G1 transition of mitotic cell cycle
- GO:0005524 ATP binding
- GO:0005654 nucleoplasm
- GO:0006270 DNA-dependent DNA replication initiation
- GO:0006271 DNA strand elongation involved in DNA replication
- GO:0006350 transcription
- View More GO Terms
- GO:0042802 identical protein binding
- GO:0045449 regulation of transcription
Request a different product with this specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up