Lyn antibody

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Rabbit anti Lyn

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00605
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human Lyn antibody recognizes the tyrosine-protein kinase Lyn, also known as lck/Yes-related novel protein tyrosine kinase, v-yes-1 or Yamaguchi sarcoma viral related oncogene homolog.

The LYN gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for LYN (provided by RefSeq, Jul 2011).

Rabbit anti Human Lyn antibody detects bands of 53 and 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Rabbit anti Lyn detects bands of approximately 53 and 56 kDa in Ramos cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide.
Immunogen
KLH conjugated synthetic peptide between amino acids 43 - 77 of human Lyn

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
P07948
Entrez Gene
LYN
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0005829 cytosol
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0006468 protein phosphorylation
GO:0006974 response to DNA damage stimulus
GO:0008284 positive regulation of cell proliferation
GO:0009725 response to hormone stimulus
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0031295 T cell costimulation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0044419 interspecies interaction between organisms
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0050900 leukocyte migration
GO:0051272 positive regulation of cellular component movement
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of Lyn antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml