LXR Beta antibody

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Anti LXR Beta Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with LXR beta antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDo MP with 119 second exposure. Arrow points to LXR beta (molecular weight 63 kDa).

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Rabbit anti LXR Beta

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: LXR Beta

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VPA00584 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human LXR beta antibody recognizes the oxysterols receptor LXR beta, also known as ubiquitously-expressed nuclear receptor, nuclear receptor NER, steroid hormone nuclear receptor NER or nuclear receptor subfamily 1 group H member 2.

The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA gene is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements (Korf et al. 2009) (supplied by OMIM, Jan 2010).

Rabbit anti Human LXR beta antibody detects a band of 63 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti LXR beta detects a band of approximately 63 kDa in A549 cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the middle region of human LXR beta
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P55055
Entrez Gene: NR1H2
GO Terms: GO:0003707 steroid hormone receptor activity; GO:0005737 cytoplasm; GO:0005654 nucleoplasm; GO:0008270 zinc ion binding; GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter; GO:0010745 negative regulation of macrophage derived foam cell differentiation; GO:0010867 positive regulation of triglyceride biosynthetic process; GO:0010875 positive regulation of cholesterol efflux; GO:0010887 negative regulation of cholesterol storage; View More GO Terms; GO:0032270 positive regulation of cellular protein metabolic process; GO:0032369 negative regulation of lipid transport; GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor; GO:0043565 sequence-specific DNA binding; GO:0045723 positive regulation of fatty acid biosynthetic process; GO:0048550 negative regulation of pinocytosis; GO:0051006 positive regulation of lipoprotein lipase activity