LXR Beta antibody
Rabbit anti Human LXR beta antibody recognizes the oxysterols receptor LXR beta, also known as ubiquitously-expressed nuclear receptor, nuclear receptor NER, steroid hormone nuclear receptor NER or nuclear receptor subfamily 1 group H member 2.
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA gene is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements (Korf et al. 2009) (supplied by OMIM, Jan 2010).
Rabbit anti Human LXR beta antibody detects a band of 63 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The liver X receptors, LXRA and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA gene is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements (Korf et al. 2009) (supplied by OMIM, Jan 2010).
Rabbit anti Human LXR beta antibody detects a band of 63 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti LXR beta detects a band of approximately 63 kDa in A549 cell lysates.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the middle region of human LXR beta
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P55055
- Entrez Gene
- NR1H2
- GO Terms
- GO:0003707 steroid hormone receptor activity
- GO:0005737 cytoplasm
- GO:0005654 nucleoplasm
- GO:0008270 zinc ion binding
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010745 negative regulation of macrophage derived foam cell differentiation
- GO:0010867 positive regulation of triglyceride biosynthetic process
- GO:0010875 positive regulation of cholesterol efflux
- GO:0010887 negative regulation of cholesterol storage
- GO:0032270 positive regulation of cellular protein metabolic process
- GO:0032369 negative regulation of lipid transport
- GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
- GO:0043565 sequence-specific DNA binding
- GO:0045723 positive regulation of fatty acid biosynthetic process
- GO:0048550 negative regulation of pinocytosis
- GO:0051006 positive regulation of lipoprotein lipase activity
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only.
Applications of LXR Beta antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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