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LOX-1 antibody

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Rabbit anti Human LOX-1 (Extracellular Domain)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
AHP1601
Datasheet
E IF*
SDS
0.1 ml loader

Rabbit anti Human LOX-1 antibody recognizes the extracellular (C-terminal) domain of human LOX-1, a receptor for oxidised low-density lipoproteins (LDL). This receptor mediates the recognition, internalisation and degradation of oxidised LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognises the ligand. LOX-1 activation by oxidised LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells.

The expression of LOX-1 is induced by proatherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis (Balzan & Lubrano 2018).

Product Details

Target Species
Human
Product Form
Serum - liquid
Antiserum Preparation
Antisera to human LOX-1 (extracellular domain) were raised by repeated immunisations of rabbits with highly purified antigen.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Peptide corresponding to the C-terminal (extracellular) region of human LOX-1.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
P78380
Entrez Gene
OLR1
GO Terms
GO:0007596 blood coagulation
GO:0005576 extracellular region
GO:0005887 integral to plasma membrane
GO:0005529 sugar binding
GO:0005624 membrane fraction
GO:0006508 proteolysis
GO:0006954 inflammatory response
GO:0008015 blood circulation
GO:0050900 leukocyte migration
Regulatory
For research purposes only

Applications of LOX-1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunofluorescence 1 1/100 1/200
  1. 1 Fixation with 4% paraformaldehyde or methanol is recommended.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

Product Specific References

References for LOX-1 antibody

  1. Chen, M. et al. (2002) LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
    Pharmacol. Ther. 95: 89-100.
  2. Li, D. et al. (2003) LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells.
    Arterioscler Thromb Vasc Biol. 23 (5): 816-21.
  3. Morawietz, H. et al. (1999) Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein.
    Circulation. 100 (9): 899-902.
  4. Sawamura, T. et al. (1997) An endothelial receptor for oxidized low-density lipoprotein.
    Nature. 386 (6620): 73-7.
  5. Yoshida, H. et al. (1998) Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor.
    Biochem J. 334 ( Pt 1): 9-13.

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