LAT1 antibody

Rabbit anti Human LAT1:Preservative Free

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
LAT1

Product Code Applications Pack Size List Price Your Price Qty
AHP1827Z
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SDS Safety Datasheet SDS
P 0.1 mg loader
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Rabbit anti Human LAT1 antibody recognizes human LAT1 (L-type amino acid transporter 1), a heterodimeric Na+-independent amino acid transporter protein and member of the amino acid-polyamine-organocation (APC) superfamily, involved in the high-affinity transport of large neutral amino acids, in association with SLC3A2/4F2hc.

LAT1 is highly expressed in the brain and is involved in the transport of L-DOPA across the blood-brain barrier, in brain neurogenesis, and acts as a mediator of L-leucine transport across the inner blood-retinal barrier. LAT1 is involved in the cell membrane transport of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the placenta, and is the foremost transporter of tyrosine in fibroblasts.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human Lat1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Keyhole limpet haemocyanin (KLH) conjugated synthetic peptide C-RHRKPEL, representing an internal portion of human LAT1 located towards the C-terminus (aa. 419-425).
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 5ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Breast

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References for LAT1 antibody

  1. Fraga, S. et al. (2005) Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.
    Amino Acids. 29 (3): 229-33.
  2. Soares-da-silva, P. et al. (2005) Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK.
    Acta Physiol Scand. 185 (1): 71-8.
  3. Pinho, M.J. et al. (2011) LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing.
    Mol Cell Biochem. 349 (1-2): 107-16.

Synonyms
L-TYPE Amino Acid Transporter 1
RRID
AB_2190981
UniProt
Q01650
Entrez Gene
SLC7A5
GO Terms
GO:0007596 blood coagulation
GO:0016021 integral to membrane
GO:0005829 cytosol
GO:0042605 peptide antigen binding
GO:0006520 cellular amino acid metabolic process
GO:0006811 ion transport
GO:0007399 nervous system development
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0016324 apical plasma membrane
GO:0030154 cell differentiation
GO:0050900 leukocyte migration
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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