LASP-1 antibody

Rabbit anti LASP-1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
LASP-1

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VPA00278
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Rabbit anti Human LASP-1 antibody recognizes LASP-1, also known as metastatic lymph node gene 50 protein.

LASP-1 is a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. Encoded by the LASP1 gene, this protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. LASP-1 has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer (provided by RefSeq, Oct 2012).

Rabbit anti Human LASP-1 antibody detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti LASP-1 detects a band of approximately 38 kDa in A431 cell lysate.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 120-148 of human LASP-1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q14847
Entrez Gene
LASP1
GO Terms
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0008270 zinc ion binding
GO:0015075 ion transmembrane transporter activity
GO:0030864 cortical actin cytoskeleton
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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