Lamin B Receptor antibody

Rabbit anti Lamin B Receptor

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Lamin B Receptor

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VPA00317
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Rabbit anti Human laminin B receptor antibody recognizes the laminin B receptor, also known as LBR, integral nuclear envelope inner membrane protein and tudor domain containing 18.

Encoded by the LBR gene, laminin B receptor belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of LBR has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified (provided by RefSeq, Jul 2008).

Rabbit anti Human laminin B receptor antibody detects a band of 67 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti lamin B receptor detects a band of approximately 67 kDa in A431 cell lysate.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose
Immunogen
Synthetic peptide corresponding to the central region of human lamin B receptor
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q14739
Entrez Gene
LBR
GO Terms
GO:0003677 DNA binding
GO:0005521 lamin binding
GO:0004872 receptor activity
GO:0005639 integral to nuclear inner membrane
GO:0006695 cholesterol biosynthetic process
GO:0050613 delta14-sterol reductase activity
GO:0070087 chromo shadow domain binding
View more products with LAMIN specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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