Sheep anti lactate dehydrogenase 5 antibody
reacts with LDH2-5, and exhibits low reactivity with LDH1. L-lactate dehydrogenase isozymes exist as tetramers of two subunits with LDH-1 composed for 4 β chains and LDH-5 composed of 4 α chains. LDH-2 =3β:1α, LDH-3 = 2β:2α, LDH-4 = 1β:3α (Boyer et al. 1963
Mutations in the LDHA gene can lead to the development of glycogen storage disease 11 (GSD11
), a condition typified by myogloinurea, fatigue and pain.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Native, highly purified lactate dehydrogenase 5.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch
- Entrez Gene
- GO Terms
L-lactate dehydrogenase activity
pyruvate metabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Lactate Dehydrogenase 5 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
Markert, C.L. (1963) Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Subunits.
Science. 140 (3573): 1329-30.
Augoff, K. et al. (2015) Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer.
Cancer Lett. 358 (1): 1-7.
Boyer, S.H. et al. (1963) Lactate dehydrogenase variant from human blood: evidence for molecular subunits.
Science. 141 (3581): 642-3.