KPNA1 antibody

Rabbit anti KPNA1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
KPNA1

Product Code Applications Pack Size List Price Your Price Qty
AHP2489
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Rabbit anti KPNA1 antibody recognizes KPNA1, also known as karyopherin alpha 1, importin subunit alpha-5, importin 5 and RCH2.

KPNA1 belongs to the importin alpha family and is involved in the import of nuclear proteins. Nuclear trafficking mediated by KPNA1 plays a key role in regulating development and differentiation.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to KPNA1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant human KPNA1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/50 1/200
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti KPNA1 antibody detects a band of approximately 60 kDa in cell lysates and tissue lysates under reducing conditions

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UniProt
P52294
Entrez Gene
KPNA1
GO Terms
GO:0000018 regulation of DNA recombination
GO:0005515 protein binding
GO:0005829 cytosol
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0006309 DNA fragmentation involved in apoptotic nuclear change
GO:0006607 NLS-bearing substrate import into nucleus
GO:0008139 nuclear localization sequence binding
GO:0008565 protein transporter activity
GO:0019058 viral infectious cycle
GO:0046796 viral genome transport in host cell
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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