KDELR1 antibody

Rabbit anti KDELR1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
KDELR1

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VPA00390
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Rabbit anti Human KDELR1 antibody recognizes KDELR1, also known as ER lumen protein retention receptor 1 and putative MAPK-activating protein PM23.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetra-peptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by the KDELR1 gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product (provided by RefSeq, Jul 2008).

Rabbit anti Human KDELR1 antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti KDELR1 detects a band of approximately 28 kDa in HEK293 cell lysate.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 185-211 of human KDELR1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P24390
Entrez Gene
KDELR1
GO Terms
GO:0005515 protein binding
GO:0016192 vesicle-mediated transport
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005046 KDEL sequence binding
GO:0005624 membrane fraction
GO:0005789 endoplasmic reticulum membrane
GO:0005793 ER-Golgi intermediate compartment
GO:0006621 protein retention in ER lumen
GO:0006886 intracellular protein transport
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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