JAK3 (pTyr980/pTyr981) antibody

Rabbit anti JAK3 (pTyr980/pTyr981)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
JAK3 (pTyr980/pTyr981)

Product Code Applications Pack Size List Price Your Price Qty
AHP2747
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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loader
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Rabbit anti JAK3 (pTyr980/pTyr981) antibody antibody recognizes tyrosine-protein kinase JAK3 when phosphorylated on tyrosine 980/981. It belongs to the JAK (Janus kinase) family of nonreceptor tyrosine kinases that are central mediators of cytokine signalling (Rane and Reddy 2000). JAK3 is expressed in hematopoietic cells (Rane and Reddy 1994). It plays important roles in development and function of the immune system (Macchi et al. 1995, Park et al. 1995). JAK3 is heavly phosphorylated on tyrosine residues tyrosine 980/981 that are located within the putative activation loop (Zhou et al. 1997).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to JAK3 (pTyr980/pTyr981) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding tyrosine 980/981 of human JAK3
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P52333
Entrez Gene
JAK3
GO Terms
GO:0005515 protein binding
GO:0016020 membrane
GO:0005829 cytosol
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005856 cytoskeleton
GO:0012505 endomembrane system
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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