JAK3 (pTyr980/pTyr981) antibody
Rabbit anti JAK3 (pTyr980/pTyr981) antibody antibody recognizes tyrosine-protein kinase JAK3 when phosphorylated on tyrosine 980/981. It belongs to the JAK (Janus kinase) family of nonreceptor tyrosine kinases that are central mediators of cytokine signalling (Rane and Reddy 2000). JAK3 is expressed in hematopoietic cells (Rane and Reddy 1994). It plays important roles in development and function of the immune system (Macchi et al. 1995, Park et al. 1995). JAK3 is heavly phosphorylated on tyrosine residues tyrosine 980/981 that are located within the putative activation loop (Zhou et al. 1997).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to JAK3 (pTyr980/pTyr981) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding tyrosine 980/981 of human JAK3
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P52333
- Entrez Gene
- JAK3
- GO Terms
- GO:0005515 protein binding
- GO:0016020 membrane
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005524 ATP binding
- GO:0005856 cytoskeleton
- GO:0012505 endomembrane system
- Regulatory
- For research purposes only
Applications of JAK3 (pTyr980/pTyr981) antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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