IRS1 (pSer636) antibody

Further Reading

1. Tzatsos, A. (2009) Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.
   J Biol Chem. 284 (34): 22525-34.
2. Zhang, J. et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.
   J Biol Chem. 283 (51): 35375-82.

UniProt

P35568

Entrez Gene

IRS1

GO Terms

GO:0005829 cytosol

GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity

GO:0005080 protein kinase C binding

GO:0005158 insulin receptor binding

GO:0005159 insulin-like growth factor receptor binding

GO:0005634 nucleus

GO:0005792 microsome

GO:0005899 insulin receptor complex

GO:0005901 caveola

View More GO Terms

GO:0008286 insulin receptor signaling pathway

GO:0008543 fibroblast growth factor receptor signaling pathway

GO:0014065 phosphatidylinositol 3-kinase cascade

GO:0046326 positive regulation of glucose import

GO:0048015 phosphatidylinositol-mediated signaling

GO:0032000 positive regulation of fatty acid beta-oxidation

GO:0042169 SH2 domain binding

GO:0042593 glucose homeostasis

GO:0043548 phosphatidylinositol 3-kinase binding

GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity

GO:0045725 positive regulation of glycogen biosynthetic process

GO:0046627 negative regulation of insulin receptor signaling pathway

GO:0046628 positive regulation of insulin receptor signaling pathway

GO:0046676 negative regulation of insulin secretion

GO:0048011 nerve growth factor receptor signaling pathway