IRAK1 antibody

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Rabbit anti IRAK1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VPA00219 Datasheet	WB SDS	100 µl	Log in		Get Quote

Rabbit anti Human IRAK1 antibody recognizes the interleukin-1 receptor-associated kinase 1 (IRAK1), also known as Pelle homolog.

IRAK1 is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation and is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for IRAK1 (provided by RefSeq, Jul 2008).

Mouse anti Human IRAK1 antibody detects a band of 76 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species: Human
Western Blotting: Anti IRAK1 detects a band of approximately 76 kDa in HeLa cell lysates
Product Form: Purified IgG - liquid
Preparation: Rabbit Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
Immunogen: KLH conjugated synthetic peptide between 683-712 amino acids from the C-terminal region of human IRAK1

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles.
Guarantee: 12 months from date of despatch

More Information

UniProt: P51617
Entrez Gene: IRAK1
GO Terms: GO:0000187 activation of MAPK activity; GO:0005515 protein binding; GO:0001959 regulation of cytokine-mediated signaling pathway; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0002756 MyD88-independent toll-like receptor signaling pathway; GO:0005829 cytosol; GO:0004704 NF-kappaB-inducing kinase activity; GO:0004842 ubiquitin-protein ligase activity; GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway; GO:0005524 ATP binding; GO:0006916 anti-apoptosis; GO:0007250 activation of NF-kappaB-inducing kinase activity; GO:0007254 JNK cascade; GO:0008063 Toll signaling pathway; GO:0010008 endosome membrane; GO:0016563 transcription activator activity; GO:0031663 lipopolysaccharide-mediated signaling pathway; GO:0032088 negative regulation of NF-kappaB transcription factor activity; GO:0034130 toll-like receptor 1 signaling pathway; GO:0034134 toll-like receptor 2 signaling pathway; GO:0034138 toll-like receptor 3 signaling pathway; GO:0034142 toll-like receptor 4 signaling pathway; GO:0042803 protein homodimerization activity; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade; GO:0045087 innate immune response; GO:0045323 interleukin-1 receptor complex; GO:0046777 protein autophosphorylation; GO:0046982 protein heterodimerization activity; GO:0048011 nerve growth factor receptor signaling pathway; GO:0051092 positive regulation of NF-kappaB transcription factor activity; GO:0051259 protein oligomerization; GO:0051403 stress-activated MAPK cascade; GO:0070498 interleukin-1-mediated signaling pathway; GO:0070555 response to interleukin-1
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory: For research purposes only

Applications of IRAK1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	List Price	Quantity
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in		Get Quote

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