IP-10 antibody




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P ResetRabbit anti Human IP-10
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- IP-10
Rabbit anti Human IP-10 antibody recognizes human IP-10 (10-kDa interferon-inducible protein), otherwise known as CXCL10, a 77 amino acid CXC chemokine which, like monokine induced by IFN-gamma (Mig) and IFN-inducible T-cell alpha-chemoattractant (I-TAC), signals through the CXCR3 receptor. IP-10 acts as a chemoattractant for Th1 lymphocytes and natural killer (NK) cells and is secreted by a variety of cells, including neutrophils, monocytes, keratinocytes and epithelial cells, in response to interferon gamma (IFNgamma) and lipopolysaccharide (LPS). IP-10 is thus associated with several clinical conditions linked with Th1 type immune responses and raised IFNgamma expression, such as psoriasis, sarcoidosis and viral meningitis. In addition, IP-10 is able to suppress the synergistic action of stimulatory cytokines on hematopoietic progenitor cell proliferation. |
- Target Species
- Human
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.1ml distilled water. For long term storage the addition of 0.09% sodium azide is recommended. NB: For functional studies do not add azide.
- Antiserum Preparation
- Antisera to human IP-10 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present.
- Carrier Free
- Yes
- Immunogen
- Recombinant human IP-10.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
0.5 | 2.0ug/ml |
Immunohistology - Paraffin 1 | ![]() |
1.0ug/ml | |
Western Blotting | ![]() |
0.1 | 0.2ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
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Further Reading
-
Cox, M.A. et al. (2001) Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states.
Mol Pharmacol. 59 (4): 707-15. -
Sauty, A. et al. (1999) The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells.
J Immunol. 162 (6): 3549-58.
- Synonyms
- CXCL10
- RRID
- AB_2087881
- UniProt
- P02778
- Entrez Gene
- CXCL10
- GO Terms
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0007166 cell surface receptor linked signaling pathway
- GO:0007267 cell-cell signaling
- GO:0007517 muscle organ development
- GO:0008009 chemokine activity
- GO:0008015 blood circulation
- GO:0008284 positive regulation of cell proliferation
- View More GO Terms
- GO:0008603 cAMP-dependent protein kinase regulator activity
AHP782

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