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IL-23 antibody

Rabbit anti Human Interleukin-23 (C-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IL-23
Region
(C-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1173
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C WB 0.1 mg loader
List Price Your Price
loader

Rabbit anti Human IL-23 antibody recognizes the C-terminal (CT) domain of human interleukin-23 (IL-23), a ~21 kDa heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.

IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human IL-23 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide (NaN3)
Immunogen
A 14 amino acid peptide from near the carboxy-terminus of human IL-23.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen 10ug/ml
Western Blotting 1 2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Raji cells.
Western Blotting
AHP1173 detects a band of approximately 24kDa in Raji cell lysates

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Further Reading

  1. Kikly, K. et al. (2006) The IL-23/Th(17) axis: therapeutic targets for autoimmune inflammation.
    Curr Opin Immunol. 18 (6): 670-5.
  2. Hu, W. et al. (2006) Interleukin 23 in acute inflammatory demyelination of the peripheral nerve.
    Arch Neurol. 63 (6): 858-64.
  3. Langrish, C.L. et al. (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity.
    Immunol Rev. 202: 96-105.
  4. Hunter, C.A. (2005) New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions.
    Nat Rev Immunol. 5 (7): 521-31.

RRID
AB_844622
UniProt
Q9NPF7
Entrez Gene
IL23A
GO Terms
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0009615 response to virus
GO:0005125 cytokine activity
GO:0006954 inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0032693 negative regulation of interleukin-10 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034105 positive regulation of tissue remodeling
GO:0042104 positive regulation of activated T cell proliferation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382 positive regulation of memory T cell differentiation
GO:0045087 innate immune response
GO:0045672 positive regulation of osteoclast differentiation
GO:0048771 tissue remodeling
GO:0050729 positive regulation of inflammatory response
GO:0051135 positive regulation of NK T cell activation
GO:0051142 positive regulation of NK T cell proliferation
GO:0070743 interleukin-23 complex

AHP1173

144587 145509 164761

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