IL-17B antibody

Rabbit anti Human INTERLEUKIN-17B:Preservative Free

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IL-17B

Product Code Applications Pack Size List Price Your Price Qty
AHP2806Z
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SDS Safety Datasheet SDS
E WB 0.1 mg loader
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Rabbit anti Human interleukin-17B antibody recognizes interleukin-17B (IL-17B) also known as cytokine Zcyto7, IL-20 and neuronal interleukin-17-related factor.

IL17B is a member of the IL-17 superfamily of cytokines and is expressed in a wide range of tissues and cell types including human pancreas, small intestine, chondrocytes and neurons. There is limited information about the biological functions of IL17B, but it is known to act as a proinflammatory cytokine inducing TNFα and IL-1β production in THP-1 cells and stimulating neutrophil infiltration (Bie et al. 2017, Liu et al. 2020). IL-17B has also been reported to induce the migration of CXCR4+ or CXCR5+ germinal center B cells to CXCL12 and CXCL13 (Bie et al. 2017).

Target Species
Human
Product Form
Purified IgG - lyophilized
Reconstitution
Reconstitute with 0.1 ml distilled water
Antiserum Preparation
Produced from sera of rabbits immunized with recombinant human interleukin-17B and purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Immunogen
E. coli derived recombinant human interleukin-17B
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml after reconstitution
Endotoxin Level
< 0.1 ng/μg of protein (< 1 EU/μg)
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.5 ug/ml 2.0 ug/ml
Western Blotting 0.1 ug/ml 0.2 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
Q9UHF5
Entrez Gene
IL17B
GO Terms
GO:0004871 signal transducer activity
GO:0005125 cytokine activity
GO:0005615 extracellular space
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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