IKK Gamma antibody
Rabbit anti Human IKK gamma antibody recognizes human inhibitor of nuclear factor kappa-B (NF-kB) kinase subunit gamma (IKK gamma).
IKK gamma is the regulatory subunit of the IKK core complex which phosphorylates the inhibitors of NF-kB, thereby leading to the dissociation of the inhibitor/NF-kB complex and eventually the degradation of the inhibitor. IKK gamma is also a mediator for TAX activation of NF-kB and might be implicated in the NF-kB mediated protection from cytokine toxicity. It is found in the heart, lung, liver, skeletal muscle, kidney and pancreas.
Rabbit anti Human IKK gamma antibody detects IKK gamma as a band of 48 kDa in a range of human cell line lysates. Cross reactivity with rodent cell lines is also observed.
IKK gamma is the regulatory subunit of the IKK core complex which phosphorylates the inhibitors of NF-kB, thereby leading to the dissociation of the inhibitor/NF-kB complex and eventually the degradation of the inhibitor. IKK gamma is also a mediator for TAX activation of NF-kB and might be implicated in the NF-kB mediated protection from cytokine toxicity. It is found in the heart, lung, liver, skeletal muscle, kidney and pancreas.
Rabbit anti Human IKK gamma antibody detects IKK gamma as a band of 48 kDa in a range of human cell line lysates. Cross reactivity with rodent cell lines is also observed.
Product Details
- Target Species
- Human
- Western Blotting
- Rabbit anti IKK gamma detects a band of approximately 48 kDa in HeLa cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to amino acids 400-416 of human IKK gamma.
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- As supplied, 12 months from date of despatch.
More Information
- UniProt
- Q9Y6K9
- Entrez Gene
- IKBKG
- GO Terms
- GO:0000187 activation of MAPK activity
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0004871 signal transducer activity
- GO:0046872 metal ion binding
- GO:0005634 nucleus
- GO:0006350 transcription
- GO:0006917 induction of apoptosis
- GO:0006974 response to DNA damage stimulus
- GO:0007254 JNK cascade
- GO:0008063 Toll signaling pathway
- GO:0019904 protein domain specific binding
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0044419 interspecies interaction between organisms
- GO:0045087 innate immune response
- GO:0050852 T cell receptor signaling pathway
- GO:0051092 positive regulation of NF-kappaB transcription factor activity
- GO:0051403 stress-activated MAPK cascade
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of IKK Gamma antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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