IKK Gamma antibody

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Rabbit anti IKK Gamma

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00084
Datasheet
WB
SDS
100 µl loader

Rabbit anti Human IKK gamma antibody recognizes human inhibitor of nuclear factor kappa-B (NF-kB) kinase subunit gamma (IKK gamma).

IKK gamma is the regulatory subunit of the IKK core complex which phosphorylates the inhibitors of NF-kB, thereby leading to the dissociation of the inhibitor/NF-kB complex and eventually the degradation of the inhibitor. IKK gamma is also a mediator for TAX activation of NF-kB and might be implicated in the NF-kB mediated protection from cytokine toxicity. It is found in the heart, lung, liver, skeletal muscle, kidney and pancreas.

Rabbit anti Human IKK gamma antibody detects IKK gamma as a band of 48 kDa in a range of human cell line lysates. Cross reactivity with rodent cell lines is also observed.

Product Details

Target Species
Human
Western Blotting
Rabbit anti IKK gamma detects a band of approximately 48 kDa in HeLa cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to amino acids 400-416 of human IKK gamma.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
Q9Y6K9
Entrez Gene
IKBKG
GO Terms
GO:0000187 activation of MAPK activity
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004871 signal transducer activity
GO:0046872 metal ion binding
GO:0005634 nucleus
GO:0006350 transcription
GO:0006917 induction of apoptosis
GO:0006974 response to DNA damage stimulus
GO:0007254 JNK cascade
GO:0008063 Toll signaling pathway
GO:0019904 protein domain specific binding
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0044419 interspecies interaction between organisms
GO:0045087 innate immune response
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of IKK Gamma antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml