IGF2BP-3 antibody

Rabbit anti IGF2BP-3

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
IGF2BP-3

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VPA00385
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Rabbit anti Human IGF2BP-3 antibody recognizes insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP-3), also known as IMP3, KH domain containing protein overexpressed in cancer, VICKZ3 and CT98.

IGF2BP-3 is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. This protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes (provided by RefSeq, Jul 2008).

Rabbit anti Human IGF2BP-3 antibody detects a band of 69 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti IGF2BP-3 detects a band of approximately 69 kDa in K562 cell lysate.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose
Immunogen
Synthetic peptide corresponding to the central region of human IGF2BP-3
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
O00425
Entrez Gene
IGF2BP3
GO Terms
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0003730 mRNA 3'-UTR binding
GO:0005829 cytosol
GO:0005634 nucleus
GO:0006412 translation
GO:0009653 anatomical structure morphogenesis
GO:0017148 negative regulation of translation
GO:0042035 regulation of cytokine biosynthetic process
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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