IGF2BP-3 antibody
Rabbit anti Human IGF2BP-3 antibody recognizes insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP-3), also known as IMP3, KH domain containing protein overexpressed in cancer, VICKZ3 and CT98.
IGF2BP-3 is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. This protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes (provided by RefSeq, Jul 2008).
Rabbit anti Human IGF2BP-3 antibody detects a band of 69 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
IGF2BP-3 is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. This protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes (provided by RefSeq, Jul 2008).
Rabbit anti Human IGF2BP-3 antibody detects a band of 69 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti IGF2BP-3 detects a band of approximately 69 kDa in K562 cell lysate
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose - Immunogen
- Synthetic peptide corresponding to the central region of human IGF2BP-3
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- As supplied, 12 months from date of despatch
More Information
- UniProt
- O00425
- Entrez Gene
- IGF2BP3
- GO Terms
- GO:0000166 nucleotide binding
- GO:0005515 protein binding
- GO:0003730 mRNA 3'-UTR binding
- GO:0005829 cytosol
- GO:0005634 nucleus
- GO:0006412 translation
- GO:0009653 anatomical structure morphogenesis
- GO:0017148 negative regulation of translation
- GO:0042035 regulation of cytokine biosynthetic process
- GO:0045182 translation regulator activity
- GO:0048027 mRNA 5'-UTR binding
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of IGF2BP-3 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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