IGF2BP-1 antibody

Rabbit anti IGF2BP-1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
IGF2BP-1

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VPA00313
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Rabbit anti Human IGF2BP-1 antibody recognizes insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP-1), also known as IGF-II mRNA-binding protein 1, VICKZ family member 1, coding region determinant-binding protein and zipcode-binding protein 1.

Encoded by the IGF2BP1 gene, insulin-like growth factor 2 mRNA-binding protein 1 contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for IGF2BP1 (provided by RefSeq, May 2009).

Rabbit anti Human IGF2BP-1 antibody detects a band of 63 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti IGF2BP-1 detects a band of approximately 63 kDa in K562 cell lysate.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 508-534 of human IGF2BP-1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q9NZI8
Entrez Gene
IGF2BP1
GO Terms
GO:0005886 plasma membrane
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0003730 mRNA 3'-UTR binding
GO:0005829 cytosol
GO:0005634 nucleus
GO:0010494 stress granule
GO:0010610 regulation of mRNA stability involved in response to stress
GO:0017148 negative regulation of translation
GO:0030027 lamellipodium
GO:0042035 regulation of cytokine biosynthetic process
GO:0043197 dendritic spine
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
GO:0070934 CRD-mediated mRNA stabilization
GO:0070937 CRD-mediated mRNA stability complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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