Rabbit anti IFNAR1 (pSer535/pSer539) antibody
recognizes IFNAR1, also known as interferon alpha/beta receptor 1, cytokine receptor family 2 member 1 or type I interferon receptor 1, when phosphorylated at serine 535/serine 539.
IFNAR1 and IFNAR2 are components of the type I interferon receptor that plays a key role in the JAK/STAT signaling pathway.
Phosphorylation of IFNAR1 at serine 535 and 539 is involved in the ubiquitination and degradation of IFNAR1 (Kumar et al. 2004
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to IFNAR1 (pSer535/pSer539) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding serine 535/serine 539 of human IFNAR1
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
response to virus
type I interferon receptor activity
integral to plasma membrane
type I interferon-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IFNAR1 (pSer535/pSer539) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Kumar, K.G. et al. (2004) Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.
J Biol Chem. 279 (45): 46614-20.