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IFIH1 antibody

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Anti Human IFIH1 (N-Terminal) Antibody thumbnail image 1
Anti Human IFIH1 (N-Terminal) Antibody gallery image 1
Immunohistochemical staining of paraffin embedded human pancreas probed with Goat anti Human IFIH1 antibody (AHP2065) at 10μgml-1 following heat mediated antigen retrieval with Tris/EDTA buffer pH9

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Goat anti Human IFIH1 (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
IFIH1
Region
(N-TERMINAL)

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Product Code Applications Pack Size List Price Your Price Qty
AHP2065
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E P * 0.1 mg
List Price Your Price

Goat anti Human IFI1 antibody recognizes human Interferon-induced helicase C domain-containing protein 1, also known as IFIH1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2 or RNA helicase-DEAD box protein 116.
Variations in the IFIH1 gene affect suceptibility to Insulin dependent diabetes mellitus 19 (IDDM19), a multifactorial disorder of glucose homeostasis with a susceptibility to ketoacidosis (Smyth et al. 2006). Mutations in the IFIH1 gene can lead to the development of Aicardi-Goutieres syndrome 7 (AGS7) a disease characterised by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection (Oda et al. 2014). Mutations in the IFIH1 gene may also lead to the development of Singleton-Merten syndrome 1 (SGMRT1), a disease featuring aortic calcification, dental abnormalities, osteopenia and acro-osteolysis (Rutsch et al. 2015).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human IFIH1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin
Immunogen
Synthetic peptide sequence SNGYSTDENFRYL-C from the N-Terminal region of IFIH1 (NP_071451.2).
Approx. Protein Concentrations
IgG concentration 0.5mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/32000
Immunohistology - Paraffin 1 10ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA buffer pH 9.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human pancreas

Description Product Code Applications Pack Size List Price Your Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F F 1 mg loader
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loader
Description Rabbit anti Goat IgG (Fc):FITC
Rabbit anti Goat IgG (Fc):HRP STAR122P C E WB 1 mg loader
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loader
Description Rabbit anti Goat IgG (Fc):HRP

Description Product Code Applications Pack Size List Price Your Price Quantity
Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
List Price Your Price
Description Antigen Retrieval Buffer, pH8.0

Synonyms
MDA5
RRID
AB_2121927
UniProt
Q9BYX4
Entrez Gene
IFIH1
GO Terms
GO:0005515 protein binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0009615 response to virus
GO:0004386 helicase activity
GO:0005829 cytosol
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0008270 zinc ion binding
GO:0042981 regulation of apoptosis
GO:0032480 negative regulation of type I interferon production
GO:0043021 ribonucleoprotein binding
GO:0044419 interspecies interaction between organisms
GO:0045087 innate immune response

AHP2065

160316

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