IFIH1 antibody
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P ResetGoat anti Human IFIH1 (N-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- IFIH1
- Region
- (N-TERMINAL)
Antibody Quality and 
Unrivaled 
| Goat anti Human IFI1 antibody recognizes human Interferon-induced helicase C domain-containing protein 1, also known as IFIH1, Clinically amyopathic dermatomyositis autoantigen 140 kDa, CADM-140 autoantigen, Helicase with 2 CARD domains, Helicard, Interferon-induced with helicase C domain protein 1, Melanoma differentiation-associated protein 5, MDA-5, Murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2 or RNA helicase-DEAD box protein 116. Variations in the IFIH1 gene affect suceptibility to Insulin dependent diabetes mellitus 19 (IDDM19), a multifactorial disorder of glucose homeostasis with a susceptibility to ketoacidosis (Smyth et al. 2006). Mutations in the IFIH1 gene can lead to the development of Aicardi-Goutieres syndrome 7 (AGS7) a disease characterised by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection (Oda et al. 2014). Mutations in the IFIH1 gene may also lead to the development of Singleton-Merten syndrome 1 (SGMRT1), a disease featuring aortic calcification, dental abnormalities, osteopenia and acro-osteolysis (Rutsch et al. 2015). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human IFIH1 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
0.5% Bovine Serum Albumin - Immunogen
- Synthetic peptide sequence SNGYSTDENFRYL-C from the N-Terminal region of IFIH1 (NP_071451.2).
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/32000 | |
| Immunohistology - Paraffin 1 | |
10ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Tris/EDTA buffer pH 9.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human pancreas
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| Description | Antigen Retrieval Buffer, pH8.0 | ||||||
- Synonyms
- MDA5
- RRID
- AB_2121927
- UniProt
- Q9BYX4
- Entrez Gene
- IFIH1
- GO Terms
- GO:0005515 protein binding
- GO:0003677 DNA binding
- GO:0003723 RNA binding
- GO:0009615 response to virus
- GO:0004386 helicase activity
- GO:0005829 cytosol
- GO:0005524 ATP binding
- GO:0005634 nucleus
- GO:0008270 zinc ion binding
- View More GO Terms
- GO:0042981 regulation of apoptosis
- GO:0032480 negative regulation of type I interferon production
- GO:0043021 ribonucleoprotein binding
- GO:0044419 interspecies interaction between organisms
- GO:0045087 innate immune response
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