Hrs / HGS antibody

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Anti Hrs / HGS Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with HRS / HGS antibody (**VPA00514**) followed by detection with Donkey anti Sheep/Goat IgG (Fc):HRP (1/10,000, STAR88P) and visualized on the ChemiDoc MP with 119 second exposure. Arrow points to HRS / HGS (molecular weight 110 kDa).

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Goat anti Hrs / HGS

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Hrs / HGS

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VPA00514 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Goat anti Human HRS / HGS antibody recognizes HRS / HGS, also known as human growth factor-regulated tyrosine kinase substrate or protein pp110.

The protein encoded by HGS regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation (provided by RefSeq, Dec 2010).

Goat anti Human HRS / HGS antibody detects a band of 110 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti HRS / HGS detects a band of approximately 110 kDa in HEK293 cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid.
Preparation: Goat polyclonal antibody purified by affinity chromatography.
Buffer Solution: TRIS buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
0.5% Bovine Serum Albumin.
Immunogen: Peptide sequence C-NRNYWEKKQEEARK
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

UniProt: O14964
Entrez Gene: HGS
GO Terms: GO:0005829 cytosol; GO:0006886 intracellular protein transport; GO:0007173 epidermal growth factor receptor signaling pathway; GO:0008270 zinc ion binding; GO:0008285 negative regulation of cell proliferation; GO:0016197 endosome transport; GO:0019904 protein domain specific binding; GO:0031901 early endosome membrane; GO:0032585 multivesicular body membrane; View More GO Terms; GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway; GO:0042176 regulation of protein catabolic process; GO:0046426 negative regulation of JAK-STAT cascade