Histone Deacetylase 5 (pSer498) antibody
Filter by Application:
WB P ResetRabbit anti Histone Deacetylase 5 (pSer498)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Histone Deacetylase 5 (pSer498)
Antibody Quality and Performance Guarantee
| Rabbit anti Histone deacetylase 5 (pSer498) antibody recognizes histone deacetylase 5, also known as HDAC5, when phosphorylated at serine 498. Histone deacetylases are chromatin-modifying enzymes that are involved in regulation of many aspects of cell biology including tissue differentiation, autophagy, apoptosis, migration, mitosis and angiogenesis. Histone deacetylase 5 is a class II histone deacetylase, which shuttles back and forth between nucleus and cytoplasm. Histone deacetylase 5 is phosphorylated at serine 498 by Protein kinase D (PKD) and Calcium/ calmodulin-dependent protein kinase (CaMK) (McKinsey et al. 2000, Ha et al. 2008). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to histone deacetylase 5 (pSer498) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding serine 498 of human histone deacetylase 5
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/100 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
 |
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:FITC | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:RPE | ||||||
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
| List Price | Your Price | ||||||
| Log in | |||||||
| Description | TidyBlot Western Blot Detection Reagent:HRP | ||||||
Further Reading
-
McKinsey, T.A. et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation.
Nature. 408 (6808): 106-11. -
Ha, C.H. et al. (2008) Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.
J Biol Chem. 283 (21): 14590-9.
- UniProt
- Q9UQL6
- Entrez Gene
- HDAC5
- GO Terms
- GO:0000118 histone deacetylase complex
- GO:0004407 histone deacetylase activity
- GO:0005080 protein kinase C binding
- GO:0005737 cytoplasm
- GO:0006338 chromatin remodeling
- GO:0006342 chromatin silencing
- GO:0006350 transcription
- GO:0006954 inflammatory response
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- View More GO Terms
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010832 negative regulation of myotube differentiation
- GO:0016566 specific transcriptional repressor activity
- GO:0016575 histone deacetylation
- GO:0030183 B cell differentiation
- GO:0032869 cellular response to insulin stimulus
- GO:0043393 regulation of protein binding
- GO:0051091 positive regulation of transcription factor activity
- GO:0070491 repressing transcription factor binding
- GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
AHP2633
141590
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with HISTONE specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up