Rabbit anti Histone deacetylase 4 (pSer632) antibody
recognizes histone deacetylase 4, also known as HDAC4, when phosphorylated at serine 632. Histone deacetylases are chromatin-modifying enzymes that are involved in the regulation of many aspects of cell biology including tissue differentiation, autophagy, apoptosis, migration, mitosis and angiogenesis. Histone deacetylase 4 is a class II histone deacetylase, which shuttles back and forth between nucleus and cytoplasm.
Histone deacetylase 4 is phosphorylated at serine 632 by calcium/calmodulin-dependent protein kinase (CaMK) (Wang et al. 2014
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to histone deacetylase 4 (pSer632) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding serine 632 of human histone deacetylase 4
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
histone deacetylase complex
histone deacetylase activity
nervous system development
zinc ion binding
positive regulation of cell proliferation
positive regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of myotube differentiation
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
transcription activator activity
specific transcriptional repressor activity
transcriptional repressor complex
B cell differentiation
potassium ion binding
positive regulation of protein sumoylation
activating transcription factor binding
histone deacetylase binding
regulation of protein binding
negative regulation of transcription factor activity
negative regulation of glycolysis
positive regulation of transcription factor activity
repressing transcription factor binding
response to interleukin-1
histone H3 deacetylation
histone H4 deacetylation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Histone Deacetylase 4 (pSer632) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Wang, Z. et al. (2014) HDAC4: mechanism of regulation and biological functions.
Epigenomics. 6 (1): 139-50.
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