Histone Deacetylase 4 antibody

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Rabbit anti Histone Deacetylase 4

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2312 P WB 50 µg
Rabbit anti histone deacetylase 4 antibody recognizes histone deacetylase 4, also known as HDAC4. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC4 belongs to the class II histone deacetylase/acuc/apha family and has been implicated to play a role in muscle maturation.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Chicken Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal
Immunogen
Synthetic peptide surrounding amino acid 10 of human HDAC4
Approx. Protein Concentrations
IgG concentration 0.2 mg/ml

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
P56524 Related reagents
Entrez Gene
HDAC4 Related reagents
GO Terms
GO:0000118 histone deacetylase complex
GO:0004407 histone deacetylase activity
GO:0006338 chromatin remodeling
GO:0006954 inflammatory response
GO:0007399 nervous system development
GO:0008270 zinc ion binding
GO:0008284 positive regulation of cell proliferation
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010832 negative regulation of myotube differentiation
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0017053 transcriptional repressor complex
GO:0030183 B cell differentiation
GO:0030955 potassium ion binding
GO:0033235 positive regulation of protein sumoylation
GO:0033613 activating transcription factor binding
GO:0034983 peptidyl-lysine deacetylation
GO:0042826 histone deacetylase binding
GO:0043393 regulation of protein binding
GO:0043433 negative regulation of transcription factor activity
GO:0045820 negative regulation of glycolysis
GO:0051091 positive regulation of transcription factor activity
GO:0070491 repressing transcription factor binding
GO:0070555 response to interleukin-1
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Regulatory
For research purposes only

Applications of Histone Deacetylase 4 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 5 ug/ml
Western Blotting 0.5 4.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti histone deacetylase 4 recognizes a band of approximately 140 kDa in Jurkat cell lysate

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB