Histone Deacetylase 4 antibody
Rabbit anti histone deacetylase 4 antibody recognizes histone deacetylase 4, also known as HDAC4. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC4 belongs to the class II histone deacetylase/acuc/apha family and has been implicated to play a role in muscle maturation.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Chicken Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal - Immunogen
- Synthetic peptide surrounding amino acid 10 of human HDAC4
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Shelf Life
- 12 months from date of despatch
More Information
- UniProt
- P56524 Related reagents
- Entrez Gene
- HDAC4 Related reagents
- GO Terms
- GO:0000118 histone deacetylase complex
- GO:0004407 histone deacetylase activity
- GO:0006338 chromatin remodeling
- GO:0006954 inflammatory response
- GO:0007399 nervous system development
- GO:0008270 zinc ion binding
- GO:0008284 positive regulation of cell proliferation
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010832 negative regulation of myotube differentiation
- GO:0014894 response to denervation involved in regulation of muscle adaptation
- GO:0014898 cardiac muscle hypertrophy in response to stress
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0017053 transcriptional repressor complex
- GO:0030183 B cell differentiation
- GO:0030955 potassium ion binding
- GO:0033235 positive regulation of protein sumoylation
- GO:0033613 activating transcription factor binding
- GO:0034983 peptidyl-lysine deacetylation
- GO:0042826 histone deacetylase binding
- GO:0043393 regulation of protein binding
- GO:0043433 negative regulation of transcription factor activity
- GO:0045820 negative regulation of glycolysis
- GO:0051091 positive regulation of transcription factor activity
- GO:0070491 repressing transcription factor binding
- GO:0070555 response to interleukin-1
- GO:0070932 histone H3 deacetylation
- GO:0070933 histone H4 deacetylation
- Regulatory
- For research purposes only
Applications of Histone Deacetylase 4 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 5 ug/ml | ||
| Western Blotting | 0.5 | 4.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti histone deacetylase 4 recognizes a band of approximately 140 kDa in Jurkat cell lysate
Copyright © 2018 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Sheep anti Rabbit IgG:Biotin | 2AB02B | 1 ml | C E P WB | ||
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | 1 mg | E WB | ||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | 1 mg | F | ||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | 1 mg | E WB | ||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | 1 mg | C E WB | ||
| Sheep anti Rabbit IgG:FITC | STAR34B | 1 mg | C F | ||
| Sheep anti Rabbit IgG:RPE | STAR35A | 1 ml | F | ||
| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | 0.1 mg | F IF WB | ||
| Sheep anti Rabbit IgG:DyLight®549 | STAR36D549GA | 0.1 mg | F IF | ||
| Sheep anti Rabbit IgG:DyLight®649 | STAR36D649GA | 0.1 mg | F IF | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | 0.1 mg | F IF WB | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | 0.1 mg | F IF WB |
