Histone Deacetylase 3 antibody

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Anti Histone Deacetylase 3 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with histone deacetylase 3 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 152 second exposure. Arrow points to histone deacetylase 3 (molecular weight 49 kDa).

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Rabbit anti Histone Deacetylase 3

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Histone Deacetylase 3

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Rabbit anti Human histone deacetylase 3 antibody recognizes histone deacetylase 3 (HDAC3), also known as SMAP45 or RPD3-2.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC3 gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is regarded as a potential tumor suppressor gene (provided by RefSeq, Jul 2008).

Rabbit anti Human histone deacetylase 3 antibody detects a band of 49 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti histone deacetylase 3 detects a band of approximately 49 kDa in NIH/3T3 cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH conjugated synthetic peptide corresponding to amino acid 383-412 of human histone deacetylase 3
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: O15379
Entrez Gene: HDAC3
GO Terms: GO:0000118 histone deacetylase complex; GO:0003714 transcription corepressor activity; GO:0004407 histone deacetylase activity; GO:0005737 cytoplasm; GO:0005876 spindle microtubule; GO:0006916 anti-apoptosis; GO:0008134 transcription factor binding; GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter; GO:0016564 transcription repressor activity; View More GO Terms; GO:0017053 transcriptional repressor complex; GO:0042826 histone deacetylase binding; GO:0044255 cellular lipid metabolic process; GO:0045786 negative regulation of cell cycle; GO:0046329 negative regulation of JNK cascade; GO:0048011 nerve growth factor receptor signaling pathway; GO:0051225 spindle assembly