Histone Deacetylase 3 antibody
Rabbit anti Histone deacetylase 3 antibody recognizes histone deacetylase 3 (HDAC3). Histone acetylation and deacetylation play important roles in modifying chromatin structure and regulating eukaryotic gene expression. HDAC3 has been characterized as a class I HDAC enzyme. HDAC3 is reported to interact with the SMRT corepressor forming a complex which inhibits histone deacetylase activity.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence Chicken Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal - Immunogen
- Synthetic peptide corresponding to the C-terminus of human HDAC3
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- O15379
- Entrez Gene
- HDAC3
- GO Terms
- GO:0000118 histone deacetylase complex
- GO:0003714 transcription corepressor activity
- GO:0004407 histone deacetylase activity
- GO:0005737 cytoplasm
- GO:0005876 spindle microtubule
- GO:0006916 anti-apoptosis
- GO:0008134 transcription factor binding
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0016564 transcription repressor activity
- GO:0017053 transcriptional repressor complex
- GO:0042826 histone deacetylase binding
- GO:0044255 cellular lipid metabolic process
- GO:0045786 negative regulation of cell cycle
- GO:0046329 negative regulation of JNK cascade
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051225 spindle assembly
- Regulatory
- For research purposes only
Applications of Histone Deacetylase 3 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 20 | 30 ug/ml | |
| Western Blotting | 0.5 | 4.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti histone deacetylase 3 recognizes a band of approximately 49 kDa in Jurkat cell lysate
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Secondary Antibodies Available
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| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
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