Histone Deacetylase 1 antibody

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Anti Histone Deacetylase 1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with histone deacetylase 1 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 65 second exposure. Arrow points to histone deacetylase 1 (molecular weight 62 kDa)

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Rabbit anti Histone Deacetylase 1

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Histone Deacetylase 1

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VPA00274 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human histone deacetylase 1 antibody recognizes the histone deacetylase 1, also known as HDAC1 and reduced potassium dependency, yeast homolog-like 1.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by the histone deacetylase 1 gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis (provided by RefSeq, Jul 2008).

Rabbit anti Human histone deacetylase 1 antibody detects a band of 62 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti histone deacetylase 1 detects a band of approximately 62 kDa in HepG2 cell lysate.
Product Form: Ig fraction - liquid
Preparation: Rabbit Ig fraction prepared by ammonium sulphate precipitation.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: KLH-conjugated synthetic peptide corresponding to aa 1-30 of human histone deacetylase 1
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: Q13547
Entrez Gene: HDAC1
GO Terms: GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0007596 blood coagulation; GO:0004407 histone deacetylase activity; GO:0005829 cytosol; GO:0006338 chromatin remodeling; GO:0006916 anti-apoptosis; GO:0008134 transcription factor binding; GO:0008284 positive regulation of cell proliferation; GO:0042802 identical protein binding; View More GO Terms; GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter; GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter; GO:0010870 positive regulation of receptor biosynthetic process; GO:0016563 transcription activator activity; GO:0016566 specific transcriptional repressor activity; GO:0016580 Sin3 complex; GO:0016581 NuRD complex; GO:0042826 histone deacetylase binding; GO:0043922 negative regulation by host of viral transcription; GO:0045786 negative regulation of cell cycle; GO:0048011 nerve growth factor receptor signaling pathway; GO:0070932 histone H3 deacetylation; GO:0070933 histone H4 deacetylation