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Histone Deacetylase 1 antibody

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Western Blot Validated
Anti Histone Deacetylase 1 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with histone deacetylase 1 antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 65 second exposure. Arrow points to histone deacetylase 1 (molecular weight 62 kDa)

Rabbit anti Histone Deacetylase 1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
PrecisionAb Antibodies
Product Code Applications Pack Size List Price Quantity
VPA00274
Datasheet
WB
SDS
100 µl loader

Rabbit anti Human histone deacetylase 1 antibody recognizes the histone deacetylase 1, also known as HDAC1 and reduced potassium dependency, yeast homolog-like 1.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by the histone deacetylase 1 gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis (provided by RefSeq, Jul 2008).

Rabbit anti Human histone deacetylase 1 antibody detects a band of 62 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti histone deacetylase 1 detects a band of approximately 62 kDa in HepG2 cell lysate
Product Form
Ig fraction - liquid
Preparation
Rabbit Ig fraction prepared by ammonium sulphate precipitation
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 1-30 of human histone deacetylase 1

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q13547
Entrez Gene
HDAC1
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0007596 blood coagulation
GO:0004407 histone deacetylase activity
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006916 anti-apoptosis
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell proliferation
GO:0042802 identical protein binding
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0042826 histone deacetylase binding
GO:0043922 negative regulation by host of viral transcription
GO:0045786 negative regulation of cell cycle
GO:0048011 nerve growth factor receptor signaling pathway
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of Histone Deacetylase 1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml

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