Histone Deacetylase 1 antibody
Rabbit anti Human histone deacetylase 1 antibody recognizes the histone deacetylase 1, also known as HDAC1 and reduced potassium dependency, yeast homolog-like 1.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by the histone deacetylase 1 gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis (provided by RefSeq, Jul 2008).
Rabbit anti Human histone deacetylase 1 antibody detects a band of 62 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by the histone deacetylase 1 gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis (provided by RefSeq, Jul 2008).
Rabbit anti Human histone deacetylase 1 antibody detects a band of 62 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti histone deacetylase 1 detects a band of approximately 62 kDa in HepG2 cell lysate
- Product Form
- Ig fraction - liquid
- Preparation
- Rabbit Ig fraction prepared by ammonium sulphate precipitation
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 1-30 of human histone deacetylase 1
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q13547
- Entrez Gene
- HDAC1
- GO Terms
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0007596 blood coagulation
- GO:0004407 histone deacetylase activity
- GO:0005829 cytosol
- GO:0006338 chromatin remodeling
- GO:0006916 anti-apoptosis
- GO:0008134 transcription factor binding
- GO:0008284 positive regulation of cell proliferation
- GO:0042802 identical protein binding
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010870 positive regulation of receptor biosynthetic process
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0016580 Sin3 complex
- GO:0016581 NuRD complex
- GO:0042826 histone deacetylase binding
- GO:0043922 negative regulation by host of viral transcription
- GO:0045786 negative regulation of cell cycle
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0070932 histone H3 deacetylation
- GO:0070933 histone H4 deacetylation
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Histone Deacetylase 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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