Histone Deacetylase 1 antibody

Rabbit anti Histone Deacetylase 1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Histone Deacetylase 1

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AHP2475
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Rabbit anti histone deacetylase 1 antibody recognizes histone deacetylase 1 also known as HDAC1. Histone deacetylases are chromatin-modifying enzymes that are involved in regulation of many aspects of cell biology including tissue differentiation, autophagy, apoptosis, migration, mitosis and angiogenesis. Class I HDACs, which include HDAC1, 2, 3 and 8 are ubiquitously expressed in all tissues and have predominantly nuclear localization.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to histone deacetylase 1 was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Recombinant human histone deacetylase 1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 1/50 1/100
Immunohistology - Paraffin 1/100 1/200
Western Blotting 1/500 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti histone deacetylase 1 antibody detects a band of approximately 62 kDa in cell lysates and tissue lysates under reducing conditions

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Synonyms
HDAC1
UniProt
Q13547
Entrez Gene
HDAC1
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0007596 blood coagulation
GO:0004407 histone deacetylase activity
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006916 anti-apoptosis
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell proliferation
GO:0042802 identical protein binding
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0042826 histone deacetylase binding
GO:0043922 negative regulation by host of viral transcription
GO:0045786 negative regulation of cell cycle
GO:0048011 nerve growth factor receptor signaling pathway
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
View more products with HISTONE specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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