Histone Deacetylase 1 antibody

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Rabbit anti Histone Deacetylase 1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
AHP2308 P WB 50 µg
Rabbit anti Histone deacetylase 1 recognizes human histone deacetylase 1 (HDAC1), also known as RPD3L1. HDAC1 is a 482 amino acid member of the histone deacetylase family responsible for the deacetylation of core histone N-terminal lysines. Histone acetylation and deacetylation play important roles in modifying chromatin structure and regulating eukaryotic gene expression. HDAC1 is a ubiquitously expressed ~62kD class I HDAC enzyme, which is related to the yeast transcriptional regulator Rpd3p (Bertos et al. 2001).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal
Immunogen
Synthetic peptide corresponding to the C-terminus of human HDAC1
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml

Storage Information

Storage
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
12 months from date of despatch

More Information

UniProt
Q13547 Related reagents
Entrez Gene
HDAC1 Related reagents
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0007596 blood coagulation
GO:0004407 histone deacetylase activity
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006916 anti-apoptosis
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell proliferation
GO:0042802 identical protein binding
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010870 positive regulation of receptor biosynthetic process
GO:0016563 transcription activator activity
GO:0016566 specific transcriptional repressor activity
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0042826 histone deacetylase binding
GO:0043922 negative regulation by host of viral transcription
GO:0045786 negative regulation of cell cycle
GO:0048011 nerve growth factor receptor signaling pathway
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Regulatory
For research purposes only

Applications of Histone Deacetylase 1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 5 ug/ml
Western Blotting 0.5 4.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Rabbit anti histone deacetylase 1 recognizes a band of approximately 62 kDa in Jurkat cell lysate

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Sheep anti Rabbit IgG:Biotin 2AB02B 1 ml C E P WB
Goat anti Rabbit IgG (Fc):Biotin STAR121B 1 mg E WB
Goat anti Rabbit IgG (Fc):FITC STAR121F 1 mg F
Goat anti Rabbit IgG (Fc):HRP STAR121P 1 mg E WB
Goat anti Rabbit IgG (H/L):HRP STAR124P 1 mg C E WB
Sheep anti Rabbit IgG:FITC STAR34B 1 mg C F
Sheep anti Rabbit IgG:RPE STAR35A 1 ml F
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:DyLight®549 STAR36D549GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®649 STAR36D649GA 0.1 mg F IF
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA 0.1 mg F IF WB
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA 0.1 mg F IF WB