Histone Deacetylase 1 antibody
Rabbit anti Histone deacetylase 1 recognizes human histone deacetylase 1 (HDAC1), also known as RPD3L1. HDAC1 is a 482 amino acid member of the histone deacetylase family responsible for the deacetylation of core histone N-terminal lysines. Histone acetylation and deacetylation play important roles in modifying chromatin structure and regulating eukaryotic gene expression. HDAC1 is a ubiquitously expressed ~62kD class I HDAC enzyme, which is related to the yeast transcriptional regulator Rpd3p (Bertos et al. 2001).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
0.01% Thiomersal - Immunogen
- Synthetic peptide corresponding to the C-terminus of human HDAC1
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q13547
- Entrez Gene
- HDAC1
- GO Terms
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0007596 blood coagulation
- GO:0004407 histone deacetylase activity
- GO:0005829 cytosol
- GO:0006338 chromatin remodeling
- GO:0006916 anti-apoptosis
- GO:0008134 transcription factor binding
- GO:0008284 positive regulation of cell proliferation
- GO:0042802 identical protein binding
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010870 positive regulation of receptor biosynthetic process
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0016580 Sin3 complex
- GO:0016581 NuRD complex
- GO:0042826 histone deacetylase binding
- GO:0043922 negative regulation by host of viral transcription
- GO:0045786 negative regulation of cell cycle
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0070932 histone H3 deacetylation
- GO:0070933 histone H4 deacetylation
- Regulatory
- For research purposes only
Applications of Histone Deacetylase 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 5 ug/ml | ||
| Western Blotting | 0.5 | 4.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti histone deacetylase 1 recognizes a band of approximately 62 kDa in Jurkat cell lysate
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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