Glycogen Phosphorylase BB antibody

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P ResetRabbit anti Human Glycogen Phosphorylase BB
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Glycogen Phosphorylase BB
Rabbit anti Human glycogen phosphorylase BB antibody detects brain glycogen phosphorylase, a regulatory enzyme which catalyses the rate-determining step in glycogen degradation. Mammalian glycogen phosphorylase is found as three major isozymes including muscle (GPMM), liver (GPLL), and brain (GPBB), which can be distinguished by their structural and functional properties as well as by the tissues in which they are expressed. GPBB is thought to function in the release of emergency glucose during stress, and in embryogenesis where it is the predominant isozyme. GPBB is also expressed in the early stages of gastric and colorectal cancers. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human brain glycogen phosphorylase were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide: internal domain of human brain glycogen phosphorylase, conjugated to Keyhole Limpet Hemocyanin.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin 1 | ![]() |
10ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Histology Positive Control Tissue
- Brain
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Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | Log in | |||
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Description | Antigen Retrieval Buffer, pH8.0 |
References for Glycogen Phosphorylase BB antibody
-
Holmes, A.P. et al. (2014) Glycogen metabolism protects against metabolic insult to preserve carotid body function during glucose deprivation.
J Physiol. 592 (Pt 20): 4493-506.
Further Reading
-
Tashima, S. et al. (2000) Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas.
Am J Gastroenterol. 95 (1): 255-63.
- Synonyms
- GPBB
- RRID
- AB_906033
- UniProt
- P11216
- Entrez Gene
- PYGB
- GO Terms
- GO:0005737 cytoplasm
- GO:0005980 glycogen catabolic process
- GO:0008184 glycogen phosphorylase activity
- GO:0030170 pyridoxal phosphate binding
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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