Glutathione Reductase antibody

Rabbit anti Glutathione Reductase

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Glutathione Reductase

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VPA00735
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Rabbit anti Human glutathione reductase antibody recognizes glutathione reductase, mitochondrial, also known as GR, GRase or epididymis luminal protein 75.

The GSR gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in GSR result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found (provided by RefSeq, Aug 2010).

Rabbit anti Human glutathione reductase antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti glutathione reductase detects a band of approximately 56 kDa in HeLa cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on Protein A.
Buffer Solution
HEPES buffered saline.
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
<50% Glycerol
Immunogen
E. coli-derived recombinant human glutathione reductase
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P00390
Entrez Gene
GSR
GO Terms
GO:0009055 electron carrier activity
GO:0005739 mitochondrion
GO:0004362 glutathione-disulfide reductase activity
GO:0005829 cytosol
GO:0055114 oxidation-reduction process
GO:0045454 cell redox homeostasis
GO:0015949 nucleobase, nucleoside and nucleotide interconversion
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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