Rabbit anti Human glucose transporter-1 antibody
recognizes human Solute carrier family 2, facilitated glucose transporter member 1, also known as GLUT-1, glucose transporter type 1, erythrocyte/brain or HepG2 glucose transporter. GLUT-1 is a 492 amino acid ~50 kDa multi-pass transmembrane glycoprotein involved in cellular uptake of glucose.
Mutations in the GLUT1 gene can lead to a number of chronic conditions including GLUT1 deficiency syndrome 1 (GLUT1DS1
), a neurologic disorder with wide phenotypic variability (Wang et al. 2005
), GLUT1 deficiency syndrome 2 (GLUT1DS2
), characterized by juvenile onset of excercise-induced dyskinesia (Weber et al. 2008
), Epilepsy, idiopathic generalized 12 (EIG12
) a condition presenting with repeated generalized seizures (Stranio et al. 2012
) and Dystonia 9 (DYT9
) a dominant inherited disorder presenting as a childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia (Weber et al. 2011
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Glucose Transporter 1 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.