Glucose Transporter 1 antibody
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Rabbit anti Human glucose transporter-1 antibody recognizes human Solute carrier family 2, facilitated glucose transporter member 1, also known as GLUT-1, glucose transporter type 1, erythrocyte/brain or HepG2 glucose transporter. GLUT-1 is a 492 amino acid ~50 kDa multi-pass transmembrane glycoprotein involved in cellular uptake of glucose.
Mutations in the GLUT1 gene can lead to a number of chronic conditions including GLUT1 deficiency syndrome 1 (GLUT1DS1), a neurologic disorder with wide phenotypic variability (Wang et al. 2005), GLUT1 deficiency syndrome 2 (GLUT1DS2), characterized by juvenile onset of excercise-induced dyskinesia (Weber et al. 2008), Epilepsy, idiopathic generalized 12 (EIG12) a condition presenting with repeated generalized seizures (Stranio et al. 2012) and Dystonia 9 (DYT9) a dominant inherited disorder presenting as a childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia (Weber et al. 2011).
Mutations in the GLUT1 gene can lead to a number of chronic conditions including GLUT1 deficiency syndrome 1 (GLUT1DS1), a neurologic disorder with wide phenotypic variability (Wang et al. 2005), GLUT1 deficiency syndrome 2 (GLUT1DS2), characterized by juvenile onset of excercise-induced dyskinesia (Weber et al. 2008), Epilepsy, idiopathic generalized 12 (EIG12) a condition presenting with repeated generalized seizures (Stranio et al. 2012) and Dystonia 9 (DYT9) a dominant inherited disorder presenting as a childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia (Weber et al. 2011).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat Bovine Expected from Sequence Cat Expected from Sequence Dog Expected from Sequence Horse Expected from Sequence Pig Expected from Sequence Rabbit Expected from Sequence Rhesus Monkey Expected from Sequence Sheep Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- 12 amino acid peptide of the C-terminus of hGLUT-1 (LFHPLGADSQV) conjugated to KLH.
- Approx. Protein Concentrations
- IgG concentration 0.1mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P11166
- Entrez Gene
- SLC2A1
- GO Terms
- GO:0016021 integral to membrane
- GO:0005624 membrane fraction
- GO:0005975 carbohydrate metabolic process
- GO:0006112 energy reserve metabolic process
- GO:0006767 water-soluble vitamin metabolic process
- GO:0050796 regulation of insulin secretion
- GO:0030496 midbody
- GO:0033300 dehydroascorbic acid transporter activity
- GO:0042470 melanosome
- GO:0055056 D-glucose transmembrane transporter activity
- Regulatory
- For research purposes only
Applications of Glucose Transporter 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunoprecipitation | 1 | 10ug/ml | |
| Western Blotting | 1 | 10ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2022 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Useful Reagents Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml |
Product Specific References
Further Reading
-
Chen, L.Y. & Phelix, C.F. (2019) Extracellular gating of glucose transport through GLUT 1.
Biochem Biophys Res Commun. Feb 26 [Epub ahead of print].
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