Gelsolin antibody

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Rabbit anti Gelsolin

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00498
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human gelsolin antibody recognizes gelsolin, also known as actin-depolymerizing factor, AGEL or brevin.

The protein encoded by GSN gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in GSN are a cause of familial amyloidosis Finnish type (AMLY5). Multiple transcript variants encoding several different isoforms have been found for GSN (provided by RefSeq, Jul 2008).

Rabbit anti Human gelsolin antibody detects a band of 90 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti gelsolin detects a band of approximately 90 kDa in HeLa cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the C terminal region of human gelsolin

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
As supplied, 12 months from date of despatch.

More Information

UniProt
P06396 Related reagents
Entrez Gene
GSN Related reagents
GO Terms
GO:0005515 protein binding
GO:0005509 calcium ion binding
GO:0003779 actin binding
GO:0051016 barbed-end actin filament capping
GO:0051014 actin filament severing
GO:0005829 cytosol
GO:0006921 cellular component disassembly involved in apoptosis
GO:0030041 actin filament polymerization
GO:0015629 actin cytoskeleton
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of Gelsolin antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml

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