Rabbit anti Gelsolin
Rabbit anti-human gelsolin antibody recognizes gelsolin, also known as actin-depolymerizing factor or brevin. This antibody has been extensively validated for western blotting using whole cell lysates.
- Product Type
- PrecisionAb™ Polyclonal
- Polyclonal IgG
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The protein encoded by GSN gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in GSN are a cause of familial amyloidosis Finnish type (AMLY5). Multiple transcript variants encoding several different isoforms have been found for GSN (provided by RefSeq, Jul 2008).
Rabbit anti Human gelsolin antibody detects a band of 90 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Anti gelsolin detects a band of approximately 90 kDa in HeLa cell lysates.
- Product Form
- Purified IgG - liquid.
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Synthetic peptide directed towards the C terminal region of human gelsolin
- Instructions For Use
- Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- As supplied, 12 months from date of despatch.
- P06396 Related reagents
- Entrez Gene
- GSN Related reagents
- GO Terms
- GO:0005515 protein binding
- GO:0005509 calcium ion binding
- GO:0003779 actin binding
- GO:0051016 barbed-end actin filament capping
- GO:0051014 actin filament severing
- GO:0005829 cytosol
- GO:0006921 cellular component disassembly involved in apoptosis
- GO:0030041 actin filament polymerization
- GO:0015629 actin cytoskeleton
- PrecisionAb™ is a trademark of Bio-Rad Laboratories.
- For research purposes only.
Applications of Gelsolin antibody
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PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
Secondary Antibodies Available
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|Goat anti Rabbit IgG (H/L):HRP||STAR208P||2 ml||WB|
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