Gelsolin antibody
Rabbit anti Human gelsolin antibody recognizes gelsolin, also known as actin-depolymerizing factor, AGEL or brevin.
The protein encoded by GSN gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in GSN are a cause of familial amyloidosis Finnish type (AMLY5). Multiple transcript variants encoding several different isoforms have been found for GSN (provided by RefSeq, Jul 2008).
Rabbit anti Human gelsolin antibody detects a band of 90 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The protein encoded by GSN gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in GSN are a cause of familial amyloidosis Finnish type (AMLY5). Multiple transcript variants encoding several different isoforms have been found for GSN (provided by RefSeq, Jul 2008).
Rabbit anti Human gelsolin antibody detects a band of 90 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti gelsolin detects a band of approximately 90 kDa in HeLa cell lysates.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the C terminal region of human gelsolin
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P06396
- Entrez Gene
- GSN
- GO Terms
- GO:0005515 protein binding
- GO:0005509 calcium ion binding
- GO:0003779 actin binding
- GO:0051016 barbed-end actin filament capping
- GO:0051014 actin filament severing
- GO:0005829 cytosol
- GO:0006921 cellular component disassembly involved in apoptosis
- GO:0030041 actin filament polymerization
- GO:0015629 actin cytoskeleton
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only.
Applications of Gelsolin antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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